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Vol. 47, No. 2, 2002
Issue release date: February 2002
Section title: Original Paper
Eur Neurol 2002;47:99–107
(DOI:10.1159/000047960)

Efficacy, Tolerability and Safety of Oral Eletriptan and Ergotamine plus Caffeine (Cafergot®) in the Acute Treatment of Migraine: A Multicentre, Randomised, Double-Blind, Placebo-Controlled Comparison

Diener H.-C. · Jansen J.-P. · Reches A. · Pascual J. · Pitei D. · Steiner T.J.
aDepartment of Neurology, University of Essen, and bSchwerpunktpraxis Schmerztherapie, Berlin, Germany; cDepartment of Neurology, Hadassah University Hospital, Jerusalem, Israel; dService of Neurology, University Hospital Marqués de Valdecilla, Santander, Spain; ePfizer Central Research, Sandwich, and fDivision of Neuroscience, Imperial College School of Medicine, London, UK

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 2/15/2002

Number of Print Pages: 9
Number of Figures: 4
Number of Tables: 2

ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)

For additional information: http://www.karger.com/ENE

Abstract

The 5-HT1B/1D/1F agonist eletriptan, at an oral dose of 80 mg, has been shown to be more efficacious than sumatriptan 100 mg and placebo in the treatment of migraine attacks with or without aura. Another commonly prescribed oral treatment for migraine attacks is Cafergot® (1 mg ergotamine tartrate with 100 mg caffeine per tablet). The efficacy, tolerability and safety of 40- and 80-mg doses of eletriptan and 2 tablets of Cafergot® were compared in a double-blind, randomised, placebo-controlled, parallel-group trial involving 733 migraine patients. Patients recorded symptoms at baseline (before treatment) and 1, 2, 4 and 24 h after dosing. Headache intensity was assessed on a 4-point scale (3 = severe pain, 2 = moderate pain, 1 = mild pain, 0 = no pain). Significantly more eletriptan-treated patients (80 mg, 68%; 40 mg, 54%) than Cafergot-treated patients (33%; p < 0.001) reported headache response (improvement from moderate-to-severe to mild or no pain) at 2 h. Substantially more eletriptan recipients reported no pain (80 mg, 38%; 40 mg, 28%; Cafergot, 10%; placebo, 5%; p < 0.001). Eletriptan headache response rates at 1 h were significantly higher (80 mg, 39%; 40 mg, 29%; Cafergot, 13%; placebo, 13%; p < 0.002 for each comparison). Both doses of eletriptan were significantly more effective than Cafergot in reducing nausea (p < 0.0001), photophobia (80 mg, p < 0.0001; 40 mg, p < 0.002), phonophobia (80 mg, p < 0.0001; 40 mg, p < 0.003) and functional impairment (p ≤ 0.001) at 2 h. Adverse events were generally mild or moderate and transient. This randomised trial shows that oral eletriptan is more efficacious in the acute treatment of migraine than oral Cafergot and is well tolerated.


  

Author Contacts

Dr. Hans-Christoph Diener
Department of Neurology
University of Essen
D–45147 Essen (Germany)
Tel. +49 201 723 2461, Fax +49 201 723 5901, E-Mail h.diener@uni-essen.de

  

Article Information

Received: Received: June 5, 2001
Accepted: September 24, 2001
Number of Print Pages : 9
Number of Figures : 4, Number of Tables : 2, Number of References : 22

  

Publication Details

European Neurology
Founded 1897 as ‘Monatsschrift für Psychiatrie und Neurologie’

Vol. 47, No. 2, Year 2002 (Cover Date: Released February 2002)

Journal Editor: J. Bogousslavsky, Lausanne
ISSN: 0014–3022 (print), 1421–9913 (Online)

For additional information: http://www.karger.com/journals/ene


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 2/15/2002

Number of Print Pages: 9
Number of Figures: 4
Number of Tables: 2

ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)

For additional information: http://www.karger.com/ENE


Copyright / Drug Dosage

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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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