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Vol. 56, No. 5-6, 2001
Issue release date: 2001
Section title: Original Paper
Horm Res 2001;56:177–181
(DOI:10.1159/000048115)

Kinetics and Effect of Percutaneous Administration of Dihydrotestosterone in Children

Charmandari E.a · Dattani M.T.a · Perry L.A.b · Hindmarsh P.C.a · Brook C.G.D.a
aLondon Centre for Paediatric Endocrinology, University College London, and bDepartment of Clinical Biochemistry, St Bartholomew’s and the Royal London Hospitals, London, UK

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 3/14/2002
Issue release date: 2001

Number of Print Pages: 5
Number of Figures: 2
Number of Tables: 1

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: http://www.karger.com/HRP

Abstract

Background: Percutaneous administration of dihydrotestosterone (DHT) has been successful in promoting phallic growth in infants and children with 5α-reductase deficiency raised as males. We investigated whether percutaneous administration of DHT is similarly effective in patients with micropenis due to alternative diagnoses. Methods: Six patients (age range 1.9–8.3 years) with micropenis of variable etiology were studied prospectively. 2.5% DHT gel was applied to the phallus once daily at a dose of 0.15–0.33 mg/kg body weight. Serum DHT concentrations were measured at 0, 2, 4, 8, 12 and 24 h following application of DHT gel. Results: Peak DHT concentrations were attained within 2–8 h after application of the gel and subsequently remained within the normal adult range in all but 1 patient, who had received the lowest dose of 0.15 mg/kg. An increase in phallic growth, ranging from 0.5–2.0 cm, was achieved after 3–4 months of treatment in all patients whose DHT concentrations were maintained within adult range. Conclusion: Percutaneous administration of DHT in a dose of 0.2–0.3 mg/kg once daily for a period of 3–4 months may be useful in the management of patients with testosterone biosynthetic defects, who have sufficient masculinization to warrant male sex assignment, or in patients with micropenis prior to reconstructive surgery.

© 2002 S. Karger AG, Basel


  

Author Contacts

Evangelia Charmandari, MD
Pediatric and Reproductive Endocrinology Branch
National Institute of Child Health and Human Development, National Institutes of Health
10 Center Drive, Building 10, Suite 9D42, Bethesda, MD 20892-1583 (USA)
Tel. +1 301 496 5800, Fax +1 301 402 0884, E-Mail charmane@mail.nih.gov

  

Article Information

Received: Received: December 28, 2000
Accepted after revision: September 25, 2001
Number of Print Pages : 5
Number of Figures : 2, Number of Tables : 1, Number of References : 17

  

Publication Details

Hormone Research (International Journal of Experimental and Clinical Endocrinology)
Founded 1970 as ‘Hormones’ by M. Marois, Continued 1976 by J. Girard (1976–1995)
Official Organ of the European Society for Paediatric Endocrinology

Vol. 56, No. 5-6, Year 2001 (Cover Date: 2001)

Journal Editor: M.B. Ranke, Tübingen
ISSN: 0301–0163 (print), 1423–0046 (Online)

For additional information: http://www.karger.com/journals/hre


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 3/14/2002
Issue release date: 2001

Number of Print Pages: 5
Number of Figures: 2
Number of Tables: 1

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: http://www.karger.com/HRP


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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