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Vol. 127, No. 1, 2002
Issue release date: January 2002
Section title: Original Paper
Int Arch Allergy Immunol 2002;127:82–88
(DOI:10.1159/000048173)

Atopic Phenotype in Children Is Associated with Decreased Virus-Induced Interferon-α Release

Bufe A.a · Gehlhar K.a · Grage-Griebenow E.a,b · Ernst M.b
aDepartment of Experimental Pneumology, Ruhr University Bochum, Bochum, bDepartment of Cell Biology, Forschungszentrum Borstel, Borstel, Germany

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 2/28/2002
Issue release date: January 2002

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 1

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA

Abstract

Background: Interferon-α (IFN-α) production in humans is an early event in the nonspecific cellular response to viruses and mediates a wide range of antiviral and immunoregulatory activities. Little is known about the role of IFN-α in allergic disease. Methods: In the present study, we performed a retrospective comparative analysis of 88 children with and without an atopic phenotype for virus-induced IFN-α production in blood cultures. Results: We were able to demonstrate that patients with allergic asthma (aA) produced significantly lower amounts of virus-induced IFN-α than healthy children and patients with nonallergic asthma (naA). Furthermore, the number of eosinophils in atopic children as a marker for allergic inflammation correlated negatively with the IFN-α level in blood cultures. Additionally, we found differences between aA and naA patients with respect to the capacity to produce IFN-γ. Although atopy is thought to be associated with a Th2 cytokine response, in our study, IFN-γ release was not reduced in the allergic children. In contrast, patients with allergic rhinitis showed a significant increase in IFN-γ release compared to naA patients. Conclusions: In our study, an early atopic phenotype was related to a reduction in virus induced IFN-α release from blood cultures. Thus, after further prospective evaluation, the IFN-α level may serve as an additional in vitro marker for the definition of atopy in children.

© 2002 S. Karger AG, Basel


  

Author Contacts

Correspondence to: Dr. A. Bufe
Ruhr University Bochum, Experimental Pneumology, BGFA XU18
Bürkle-de-la-Camp-Platz 1
D–44789 Bochum (Germany)
Tel. +49 234 3074 510, E-Mail albrecht.bufe@ruhr-uni-bochum.de

  

Article Information

Received: Received: April 24, 2001
Accepted after revision: July 18, 2001
Number of Print Pages : 7
Number of Figures : 3, Number of Tables : 1, Number of References : 41

  

Publication Details

International Archives of Allergy and Immunology
Founded 1950

Vol. 127, No. 1, Year 2002 (Cover Date: January 2002)

Journal Editor: D. Kraft, Vienna
ISSN: 1018–2438 (print), 1423–0097 (Online)

For additional information:http://www.karger.com/journals/iaa


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 2/28/2002
Issue release date: January 2002

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 1

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA


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