Continuous Intrathecal Clonidine Administration for the Treatment of Neuropathic PainUhle E.-I. · Becker R. · Gatscher S. · Bertalanffy H.
Department of Neurosurgery, Philipps University Marburg, Germany
In many cases, the treatment of neuropathic pain by intrathecal opioids fails to meet expectations. In a trial involving 10 patients, the intrathecal administration of clonidine combined with opioids in the treatment of chronic pain was introduced in our department for the first time. Eight patients with neuropathic pain syndromes were subjected to a continuous intrathecal clonidine application in addition to intrathecal morphine. At an average dose of 44 µg clonidine/day, a 70–100% reduction in pain was achieved. Residual non-neuropathic pain in 4 of 8 patients was successfully treated with clonidine and low doses of opioids. On the basis of the results achieved so far, we recommend that clonidine should be routinely tested for intrathecal drug administration, especially in patients with a prominent neuropathic pain component.
Dr. med. E.-I. Uhle
Klinik für Neurochirurgie, Philipps-Universität Marburg
Baldingerstrasse, D–35043 Marburg (Germany)
Tel. +49 6421 286 6448, Fax +49 6421 286 6415
Number of Print Pages : 9
Number of Figures : 0, Number of Tables : 3, Number of References : 24
Stereotactic and Functional Neurosurgery (Official Journal of the World Society for Stereotactic and Functional Neurosurgery; Official Journal of the American Society for Stereotactic and Functional Neurosurgery)
Founded 1938 as ‘Confinia Neurologica’ by E.A. Spiegel; Continued 1975–1988 as ‘Applied Neurophysiology’
Vol. 75, No. 4, Year 2000 (Cover Date: Released March 2002)
Journal Editor: Ph.L. Gildenberg, Houston, Tex.
ISSN: 1011–6125 (print), 1423–0372 (Online)
For additional information: http://www.karger.ch/journals/sfn