In many cases, the treatment of neuropathic pain by intrathecal opioids fails to meet expectations. In a trial involving 10 patients, the intrathecal administration of clonidine combined with opioids in the treatment of chronic pain was introduced in our department for the first time. Eight patients with neuropathic pain syndromes were subjected to a continuous intrathecal clonidine application in addition to intrathecal morphine. At an average dose of 44 µg clonidine/day, a 70–100% reduction in pain was achieved. Residual non-neuropathic pain in 4 of 8 patients was successfully treated with clonidine and low doses of opioids. On the basis of the results achieved so far, we recommend that clonidine should be routinely tested for intrathecal drug administration, especially in patients with a prominent neuropathic pain component.
© 2002 S. Karger AG, Basel
Number of Print Pages : 9
Number of Figures : 0, Number of Tables : 3, Number of References : 24
Stereotactic and Functional Neurosurgery (Official Journal of the World Society for Stereotactic and Functional Neurosurgery; Official Journal of the American Society for Stereotactic and Functional Neurosurgery)
Founded 1938 as ‘Confinia Neurologica’ by E.A. Spiegel; Continued 1975–1988 as ‘Applied Neurophysiology’
Vol. 75, No. 4, Year 2000 (Cover Date: Released March 2002)
Journal Editor: Ph.L. Gildenberg, Houston, Tex.
ISSN: 1011–6125 (print), 1423–0372 (Online)
For additional information: http://www.karger.ch/journals/sfn
Article / Publication Details
Published online: 3/20/2002
Issue release date: March 2002
Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 3
ISSN: 1011-6125 (Print)
eISSN: 1423-0372 (Online)
For additional information: http://www.karger.com/SFN
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