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Vol. 48, No. 1, 2002
Issue release date: March 2002
Section title: Experimental Chemotherapy
Chemotherapy 2002;48:42–48
(DOI:10.1159/000048587)

Protection Effects of Taurine Supplementation against Cisplatin-Induced Nephrotoxicity in Rats

Saad S.Y.a · Al-Rikabi A.C.b
aDepartment of Clinical Pharmacy, College of Pharmacy and bDepartment of Pathology, College of Medicine, King Saud University, Riyadh, Saudi Arabia

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Article / Publication Details

First-Page Preview
Abstract of Experimental Chemotherapy

Published online: 10/29/2010
Issue release date: March 2002

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 3

ISSN: 0009-3157 (Print)
eISSN: 1421-9794 (Online)

For additional information: http://www.karger.com/CHE

Abstract

Backgound: Taurine, which is the major intracellular free β-amino acid, is known to be an antioxidant and a membrane-stabilizing agent. This study was designed to investigate the protective role of taurine supplementation against cisplatin-induced nephrotoxicity. Methods: Male Wistar rats were divided into six groups and treated as follows: (1) saline-treated control drinking tap water, (2) saline-treated plus taurine-supplemented (1.5% taurine in the drinking water), (3) saline-treated plus taurine-depleted (3% β-alanine in the drinking water), (4) cisplatin-treated, CDDP 6 mg/kg intraperitoneally, (5) taurine-supplemented plus CDDP-treated and (6) taurine-depleted plus CDDP-treated. Rats were sacrificed 7 days after CDDP treatment, and serum as well as kidneys were isolated and analyzed. Results: CDDP-treated rats showed increased kidney weight as a percentage of total body weight, serum creatinine and BUN levels and decreased serum albumin and calcium levels. Also, CDDP treatment resulted in a depletion of kidney GSH content, a reduction in the kidney glutathione peroxidase (GSH-Px) activity and increased kidney MDA production level. Taurine supplementation attenuated CDDP-induced nephrotoxicity which was manifested by jeopardizing the elevation in serum creatinine and BUN levels and the reduction in serum albumin and calcium levels. Moreover, taurine supplementation restored kidney GSH content and GSH-Px activity and reduced platinum accumulation and MDA production levels in the kidney tissue following CDDP treatment. Histopathological examination of the kidney of CDDP-treated rats revealed tubular atrophy, tubular necrosis and desquamation of renal tubular cells. However, taurine supplementation protected against CDDP-induced histopathological changes. Conclusions: The data suggest that taurine supplementation effectively attenuates the accumulation of platinum within kidney tissue and counteracts the deleterious effect of CDDP on the renal tubular function.

© 2002 S. Karger AG, Basel


  

Author Contacts

Dr. Sherif Y. Saad
Department of Clinical Pharmacy, College of Pharmacy
King Saud University, PO Box 2457
Riyadh 11451 (Saudi Arabia), Tel. +966 1 467 74 47
Fax +966 1 4672599, E-Mail sherif_ibrahem@hotmail.com

  

Article Information

Number of Print Pages : 7
Number of Figures : 1, Number of Tables : 3, Number of References : 36

  

Publication Details

Chemotherapy (International Journal of Experimental and Clinical Chemotherapy)
Founded 1959 as ‘Chemotherapia’

Vol. 48, No. 1, Year 2002 (Cover Date: March 2002)

Journal Editor: H. Schönfeld, Grenzach-Wyhlen
ISSN: 0009–3157 (print), 1421–9794 (Online)

For additional information:http://www.karger.com/journals/che


Article / Publication Details

First-Page Preview
Abstract of Experimental Chemotherapy

Published online: 10/29/2010
Issue release date: March 2002

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 3

ISSN: 0009-3157 (Print)
eISSN: 1421-9794 (Online)

For additional information: http://www.karger.com/CHE


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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