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Vol. 21, No. 2, 2002
Issue release date: March–April 2002
Section title: Original Paper
Neuroepidemiology 2002;21:58–67
(DOI:10.1159/000048618)

Impaired Olfaction Predicts Cognitive Decline in Nondemented Older Adults

Swan G.E. · Carmelli D.
Center for Health Sciences, SRI International (formerly Stanford Research Institute), Menlo Park, Calif., USA

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 3/15/2002
Issue release date: March–April 2002

Number of Print Pages: 10
Number of Figures: 0
Number of Tables: 5

ISSN: 0251-5350 (Print)
eISSN: 1423-0208 (Online)

For additional information: http://www.karger.com/NED

Abstract

In 1992, the twelve-item Brief Smell Identification Test® and, in 1992 and 1996, a variety of measures of verbal learning and memory, executive control, and global function were administered to a total of 359 individuals (286 men and 73 women; mean age in 1992 74.3 years). Individuals with a history of stroke or impaired cognition at baseline were excluded from analyses. Impaired olfactory function (present or absent) was related to a greater 4.5-year decline on several indices of verbal memory, but not to a decline on measures of executive control or of global functioning after adjustment for baseline cognitive performance, age, education, gender, and history of smell difficulties. Olfactory loss remained associated with a decline in components of verbal memory, independently of the apolipoprotein E ε4 status. The predictive utility of impaired smell identification in older adults appears to be specific to a decline in components of verbal memory.

© 2002 S. Karger AG, Basel


  

Author Contacts

Gary E. Swan, PhD
Center for Health Sciences, SRI International
333 Ravenswood Avenue
Menlo Park, CA 94025 (USA)
Tel. +1 650 859 5322, Fax +1 650 859 5099, E-Mail gswan@unix.sri.com

  

Article Information

Number of Print Pages : 10
Number of Figures : 0, Number of Tables : 5, Number of References : 64

  

Publication Details

Neuroepidemiology
Founded 1982 by B.S. Schoenberg, continued by M. Alter (1989–1996)

Vol. 21, No. 2, Year 2002 (Cover Date: March-April 2002)

Journal Editor: G.C. Román, San Antonio, Tex.
ISSN: 0251–5350 (print), 1423–0208 (Online)

For additional information: http://www.karger.com/journals/ned


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 3/15/2002
Issue release date: March–April 2002

Number of Print Pages: 10
Number of Figures: 0
Number of Tables: 5

ISSN: 0251-5350 (Print)
eISSN: 1423-0208 (Online)

For additional information: http://www.karger.com/NED


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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