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Table of Contents
Vol. 94, No. 3-4, 2001
Issue release date: 2001
Section title: Gene Mapping, Cloning and Sequencing
Cytogenet Cell Genet 94:131–136 (2001)
(DOI:10.1159/000048804)

PHF3 expression is frequently reduced in glioma

Fischer U.a · Struss A.-K.a · Hemmer D.a · Michel A.a · Henn W.a · Steudel W.-I.b · Meese E.a
aInstitut für Humangenetik, Universität des Saarlandes, und bNeurochirurgische Universitätsklinik, Homburg/Saar (Germany)

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Article / Publication Details

First-Page Preview
Abstract of Gene Mapping, Cloning and Sequencing

Published online: February 19, 2002
Issue release date: 2001

Number of Print Pages: 6
Number of Figures: 3
Number of Tables: 1

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: http://www.karger.com/CGR

Abstract

Glioblastoma is the most frequent brain tumor and accounts for approximately 50–60% of all astrocytic tumors. Many chromosome alterations have been described in glioblastoma, but only for a few alterations were the genes identified and linked to genetic pathways in glioblastoma development. To contribute to the identification of novel genes involved in glioblastoma development we used a combined immunological and molecular screening approach. Here we report the identification and expression analysis of a novel gene from human chromosome 6q12 that is considered to be the third member of a family of PHD finger containing genes and is termed PHF3. PHF3 is ubiquitously expressed in normal tissues including brain, but its expression is significantly reduced or lost in glioblastoma, glioblastoma cell lines, anaplastic astrocytomas and astrocytomas. The PHF3 protein sequence contains several protein motifs frequently found in transcription factors. One of those motifs is a PHD finger, also termed LAP motif and known to bind large portions of DNA. Another region of the protein revealed a high homology to the transcription factor TFIIS, especially to a region that is necessary for the Polymerase II binding properties of TFIIS. Combining these results, PHF3 is a novel member of a large class of regulatory proteins containing a LAP motif, and loss of its expression in glioblastoma may contribute to glioma development.   

© 2002 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Gene Mapping, Cloning and Sequencing

Published online: February 19, 2002
Issue release date: 2001

Number of Print Pages: 6
Number of Figures: 3
Number of Tables: 1

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: http://www.karger.com/CGR


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