Human and mouse orthologs of a new ATP-binding cassette gene, ABCG4Annilo T.a · Tammur J.b,f · Hutchinson A.b · Rzhetsky A.d,e · Dean M.a · Allikmets R.b,c
aLaboratory of Genomic Diversity, NCI-FCRDC, Frederick, MD; Departments of bOphthalmology, cPathology, dMedical Informatics, and eColumbia Genome Center, Columbia University, New York, NY (USA); fDepartment of Biotechnology, Institute of Molecular and Cell Biology, Tartu University, Tartu,(Estonia)
We characterized a new ATP-binding cassette (ABC) transporter gene from human and mouse that is highly expressed in the brain. The gene, ABCG4, produces several transcripts that differ at the 5′ end and encode proteins of various lengths. The ABCG4 protein is closely related to the Drosophila white and human ABCG1 genes, and belongs to the ABCG subfamily several members of which are involved in cholesterol transport. All representatives of this “reverse transporter” subfamily, including ABCG4, have a single ATP-binding domain at the N-terminus and a single C-terminal set of transmembrane segments. ABCG4 maps to human chromosome 11q23, between the markers D11S939 and D11S924, and Abcg4 to a conserved syntenic region on mouse chromosome 9. The abundant expression of this gene in the brain and close evolutionary relationship to the other members of the subfamily suggests a potential role for ABCG4 in cholesterol transport processes in this tissue.
© 2002 S. Karger AG, Basel
Request reprints from Rando Allikmets, Department of Ophthalmology,Columbia University, Eye Research Addition,Rm 715, 630 West 168th Street, New York NY 10032 (USA);telephone: 212-305-8989; fax: 212-305-7014; e-mail: firstname.lastname@example.org
T.A. and J.T. contributed equally to the study.
Supported in part by grants from Research to Prevent Blindness, Inc., New York NY, by the Steinbach Fund New York NY, and NIH/NEI grant EY-13435 to R.A.
Received: Received 26 September 2001;
manuscript accepted 23 October 2001.
Number of Print Pages : 6
Number of Figures : 5, Number of Tables : 0, Number of References : 19
Cytogenetics and Cell Genetics
Founded 1962 as Cytogenetics by H.P. Klinger
Vol. 94, No. 3-4, Year 2001 (Cover Date: 2001)
Journal Editor: H.P. Klinger, Bronx, N.Y.; M. Schmid, Würzburg
ISSN: 0301–0171 (print), 1422–9816 (Online)
For additional information: http://www.karger.com/journals/ccg