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Vol. 64, No. 1, 2001
Issue release date: 2001
Section title: Original Paper: Esophagus
Digestion 2001;64:1–8
(DOI:10.1159/000048833)

Dilated Intercellular Spaces as Markers of Reflux Disease: Histology, Semiquantitative Score and Morphometry upon Light Microscopy

Villanacci V. · Grigolato P.G. · Cestari R. · Missale G. · Cengia G. · Klersy C. · Rindi G.
aPathology Service 2, bDepartment of Surgery (Digestive Endoscopy), University of Brescia and Spedali Civili, Brescia, and cBiometric and Clinical Epidemiology Service, IRCCS Policlinico San Matteo, Pavia, Italy

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Article / Publication Details

First-Page Preview
Abstract of Original Paper: Esophagus

Published online: 9/10/2001

Number of Print Pages: 8
Number of Figures: 2
Number of Tables: 3

ISSN: 0012-2823 (Print)
eISSN: 1421-9867 (Online)

For additional information: http://www.karger.com/DIG

Abstract

Background and Aims: A recent electron microscopy study suggested that dilated intercellular spaces (DIS) are specific for acid reflux-damaged esophageal epithelium. Electron microscopy is, however, expensive and difficult to apply to routine biopsies. The aims of this study are to establish a method for assessing DIS on light microscopy of esophageal biopsies and to estimate its association with current clinicopathological parameters of esophagitis. Materials and Methods: 21 patients with reflux symptoms were investigated. Light microscopy biopsies were assessed for DIS size by a semiquantitative method and computer-assisted, static morphometry. A DIS score accounting for DIS size and distribution was assigned to each patient and its association with 30 clinicopathological variables investigated by univariate and multivariate logistic regression. Results: Both the semiquantitative method and static morphometry identified 4 different classes of DIS size. The DIS score was significantly and independently associated with the esophageal symptoms score, the histological score of esophagitis and the relevant morphometry data. Conclusions: DIS may be efficiently assessed during light microscopy of routine esophageal biopsies. Since correlation with both the histology and the symptoms of esophagitis, the DIS score may be considered a novel parameter of esophagitis and is suggested for the routine evaluation of esophageal biopsies in patients with reflux disease.


  

Author Contacts

Guido Rindi MD, PhD
Anatomia Patologica 2
Piazza Spedali Civili, 1
I–25124 Brescia (Italy)
Tel. +39 030 3995 830, Fax +39 030 3995 053, E-Mail rindi@master.cci.unibs.it

  

Article Information

Supported by the University of Brescia (G.R. and P.G.G.) and COFIN 99 (G.R.).

Received: Received: October 19, 2000
Accepted: January 23, 2001
Number of Print Pages : 8
Number of Figures : 2, Number of Tables : 3, Number of References : 17

  

Publication Details

Digestion (International Journal of Gastroenterology)
Founded as Archiv für Verdauungskrankheiten, 1895; continued as Gastroenterologia, 1939-1967

Vol. 64, No. 1, Year 2001 (Cover Date: 2001)

Journal Editor: R. Arnold, Marburg
ISSN: 0012–2823 (print), 1421–9867 (Online)

For additional information: http://www.karger.com/journals/dig


Article / Publication Details

First-Page Preview
Abstract of Original Paper: Esophagus

Published online: 9/10/2001

Number of Print Pages: 8
Number of Figures: 2
Number of Tables: 3

ISSN: 0012-2823 (Print)
eISSN: 1421-9867 (Online)

For additional information: http://www.karger.com/DIG


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