Subcortical Vascular DementiaErkinjuntti T.
Memory Research Unit, Department of Clinical Neurosciences, University of Helsinki, Finland
Vascular dementia (VaD) incorporates different vascular mechanisms and changes in the brain, and has different causes and clinical manifestations. Current criteria for VaD select an aetiologically and clinically heterogeneous group and this definitional heterogeneity has affected clinical trial results. Focus on a more homogeneous group, such as that with subcortical (ischaemic) VaD, could be an alternative in clinical drug trials. This subtype incorporates two small vessel clinical entities – ‘Binswanger’s disease’ and ‘the lacunar state’. It comprises small vessel disease as the primary vascular aetiology, lacunar infarct(s) and ischaemic white matter lesions as the primary type of brain lesions, subcortical location as the primary location of lesions, and the subcortical clinical syndrome as the primary clinical manifestation. Subcortical VaD is expected to show a more predictable clinical picture, natural history, outcome and treatment responses.
Timo Erkinjuntti, MD, PhD
Memory Research Unit, Department of Clinical Neurosciences
Helsinki University Central Hospital
PO Box 300, FIN–00290 Hyks (Finland)
Tel. +358 9 471 7 2353, Fax +358 9 471 7 5550, E-Mail email@example.com
Number of Print Pages : 3
Number of Figures : 0, Number of Tables : 2, Number of References : 27
Cerebrovascular Diseases (Official Journal of the European Stroke Council)
Vol. 13, No. Suppl. 2, Year 2002 (Cover Date: Released March 2002)
Journal Editor: J. Bogousslavsky, Lausanne; M.G. Hennerici, Mannheim
ISSN: 1015–9770 (print), 1421–9786 (Online)
For additional information: http://www.karger.com/journals/ced