Over the past decade, antiproliferative effects of somatostatin and analogs have been reported in many somatostatin receptor-positive normal and tumor cell types. Regarding the molecular mechanisms involved, somatostatin or analogs mediate their action through both indirect and direct effects. Somatostatin acts through five somatostatin receptors (SSTR1–5) which are variably expressed in normal and tumor cells. These receptors regulate a variety of signal transduction pathways including inhibition of adenylate cyclase, regulation of ion channels, regulation of serine/threonine and tyrosine kinases and phosphatases. This review focuses on recent advances in biological mechanisms involved in the antineoplastic activity of somatostatin and analogs.
Dr. Christiane Susini
INSERM U151, Institut Louis Bugnard, IFR 31
CHU Rangueil, F–31403 Toulouse Cedex 4 (France)
Tel. +33 5 61 32 24 07, Fax +33 5 61 32 24 03
Number of Print Pages : 10
Number of Figures : 0, Number of Tables : 0, Number of References : 59
Chemotherapy (International Journal of Experimental and Clinical Chemotherapy)
Founded 1959 as ‘Chemotherapia’
Vol. 47, No. Suppl. 2, Year 2001 (Cover Date: Released January 2001)
Journal Editor: H. Schönfeld, Grenzach-Wyhlen
ISSN: 0009–3157 (print), 1421–9794 (Online)
For additional information:http://www.karger.com/journals/che
Article / Publication Details
Published online: 3/12/2001
Issue release date: 2001
Number of Print Pages: 10
Number of Figures: 0
Number of Tables: 0
ISSN: 0009-3157 (Print)
eISSN: 1421-9794 (Online)
For additional information: http://www.karger.com/CHE
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