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Vol. 15, No. 2, 2002
Issue release date: March–April 2002
Section title: Original Research Article
Skin Pharmacol Appl Skin Physiol 2002;15:120–124
(DOI:10.1159/000049399)

Modulating Effects of Oatmeal Extracts in the Sodium Lauryl Sulfate Skin Irritancy Model

Vié K. · Cours-Darne S. · Vienne M.P. · Boyer F. · Fabre B. · Dupuy P.
Pierre-Fabre Research Institute,aToulouse, bCastanet Tolosan, and Pierre-Fabre Dermo-Cosmetic, cLavaur, dRamonville, France

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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Published online: 2/28/2002
Issue release date: March–April 2002

Number of Print Pages: 5
Number of Figures: 2
Number of Tables: 1

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: http://www.karger.com/SPP

Abstract

The aim of the present study was to assess the anti-inflammatory activity of two topically applied oatmeal extracts, i.e. Avena sativa and Avena Rhealba®, using the sodium lauryl sulfate (SLS) irritation model. At baseline, test areas on the volar surface of the upper arms of 12 healthy individuals were pretreated with the two extracts and their vehicle (petrolatum ointment) under occlusion for 2 h, and one site was left untreated. Then a patch with a 1% SLS solution was applied to the test sites for 24 h. Irritation was determined at each period by measuring by chromametry and laser-Doppler. In a dose-ranging study with the Avena Rhealba extract alone, the 20 and 30% concentrations exerted a slight inhibition of the a* parameter increase and a marked reduction of the blood flow increase (p < 0.05, compared to vehicle). Then, the effects of the two extracts at the concentration of 20% were compared. All extracts displayed a statistically significant counteracting effect on both parameters (p < 0.05), but no statistically significant difference between treatment groups could be demonstrated. In conclusion, this study demonstrates the preventive effects of oatmeal extracts on skin irritation in the SLS model.


  

Author Contacts

P. Dupuy, MD
Pierre-Fabre Research Institute, Allée Camille Soula, BP 74, Vigoulet
F–31322 Castanet Tolosan Cedex (France)
Tel. +33 5 61 75 52 74, Fax +33 5 61 75 52 52
E-Mail patrick.dupuy@pierre-fabre.com

  

Article Information

Received: Received: July 24, 2000
Accepted: Sept. 27, 2000
Number of Print Pages : 5
Number of Figures : 2, Number of Tables : 1, Number of References : 6

  

Publication Details

Skin Pharmacology and Applied Skin Physiology (Journal of Pharmacological and Biophysical Research)
Incorporating ‘Bioengineering and the Skin’; Founded in 1988 by H. Schaefer
Official Journal of the Skin Pharmacology Society (SPS)

Vol. 15, No. 2, Year 2002 (Cover Date: March-April 2002)

Journal Editor: Hans F. Merk, Aachen
ISSN: 1422–2868 (print), 1422–2906 (Online)

For additional information: http://www.karger.com/journals/sph


Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Published online: 2/28/2002
Issue release date: March–April 2002

Number of Print Pages: 5
Number of Figures: 2
Number of Tables: 1

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: http://www.karger.com/SPP


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