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Vol. 53, No. 1, 2002
Issue release date: January 2002
Section title: Original Paper
Gynecol Obstet Invest 2002;53:28–31
(DOI:10.1159/000049407)

Maternal Serum Levels of Human Chorionic Somatotropin Correlates with Transferrin and Erythropoietin in Pregnancy

Carretti N. · la Marca A.
Department of Obstetrics and Gynaecology, University of Siena, Italy

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 1/18/2002
Issue release date: January 2002

Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 3

ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)

For additional information: http://www.karger.com/GOI

Abstract

During pregnancy, plasma levels of erythropoietin (EPO) and transferrin (TSF) show a gradual increase till term, when a slight decrease occurs. Human chorionic somatotropin (hCS) is a peptide hormone with a direct effect on the function of the syncytiotrophoblast and on the mass of functional placental tissue. In order to understand the relationships between the placental functions, maternal erythropoiesis and iron transfer to the fetus, the relationships between EPO and hCS and between TSF and hCS were investigated. A group of healthy pregnant women (n = 190) attending the Obstetric Clinic of the University of Siena were studied. They were between 18 and 43 weeks pregnant. A single blood sample was taken from each patient by radial vein puncture on admission into the clinic before the beginning of any therapy, for the determination of haemoglobin, EPO, ferritin, serum iron, TSF and hCS. The highest correlation was that between hCS and TSF (r = 0.336, p < 0.0001). This correlation was significant in anaemic patients and lost its significance in non-anaemic patients. In our study, we also found a significant relationship between hCS and logEPO (r = 0.195; p < 0.01) which reached an elevated significance over the entire survey, but did not reach statistical significance in anaemic women. We hypothesise that in pregnancy chorionic villi develop a great capacity to respond to pathological maternal events with the result of regulating the transport of iron, the oxygen tension and the maternal-fetal transfer of oxygen through haemoglobin. Evidently, the response of the villi serves to balance the lack of iron in favour of the fetus, probably through a mechanism that links the variations of the iron transport on the maternal side and the increased use on the fetal side through a dynamic and consensual response by the chorionic villi.

© 2002 S. Karger AG, Basel


  

Author Contacts

N. Carretti, MD
Department of Obstetrics and Gynaecology
University of Siena
I–53100 Siena (Italy)
Tel. +39 0577 233463, Fax +39 0577 233454, E-Mail carretti@unisi.it

  

Article Information

Received: Received: December 28, 2000
Revised and accepted: July 19, 2001
Number of Print Pages : 4
Number of Figures : 1, Number of Tables : 3, Number of References : 12

  

Publication Details

Gynecologic and Obstetric Investigation
Founded 1895 as ‘Monatsschrift für Geburtshilfe und Gynäkologie’, continued 1946–1969 as ‘Gynaecologia’ and 1970 –1977 as ‘Gynecologic Investigation’

Vol. 53, No. 1, Year 2002 (Cover Date: Released January 2002)

Journal Editor: G. Zador, Södertälje
ISSN: 0378–7346 (print), 1423–002X (Online)

For additional information: http://www.karger.com/journals/goi


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 1/18/2002
Issue release date: January 2002

Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 3

ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)

For additional information: http://www.karger.com/GOI


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