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Table of Contents
Vol. 126, No. 3, 2001
Issue release date: November 2001
Section title: Original Paper
Int Arch Allergy Immunol 2001;126:231–238
(DOI:10.1159/000049519)

The Prevalence of Parasite Infestation and House Dust Mite Sensitization in Gabonese Schoolchildren

van den Biggelaar A.H.J.a,d · Lopuhaa C.b · van Ree R.c · van der Zee J.S.b · Jans J.a,d · Hoek A.a,d · Migombet B.d · Borrmann S.d,e · Luckner D.d,e · Kremsner P.G.d,e · Yazdanbakhsh M.a
aDepartment of Parasitology, Leiden University Medical Center, Leiden, and bDepartment of Pulmonology, Academic Medical Center and cDepartment of Allergy, Central Laboratory for Blood Transfusion, Amsterdam, The Netherlands; dResearch Unit, Albert Schweitzer Hospital, Lambarene, Gabon; eDepartment of Parasitology, Institute for Tropical Medicine, University of Tübingen, Germany

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: December 14, 2001
Issue release date: November 2001

Number of Print Pages: 8
Number of Figures: 1
Number of Tables: 4

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA

Abstract

Background: Allergic diseases seem less prevalent in communities in less developed parts of the world, where parasite infections are highly prevalent. Altogether not much is known about the association between chronic infections with tissue and blood-dwelling parasites and atopy. Methods: In an area in Gabon endemic for blood and tissue parasites, 520 schoolchildren were parasitologically examined and skin prick-tested for a set of common environmental aeroallergens. Levels of allergen-specific IgE and polyclonal IgE were measured. Results: In schoolchildren schistosome and filarial infections increased with age, whereas malaria was more prevalent in younger children. In contrast to allergen sensitization that increased with age, skin test reactivity tended to decline. The number of children with mite-specific IgE antibodies (47%) by far exceeded the number responding to skin prick testing (11%). Mite sensitization was found to be the highest in children infected with schistosomes and/or filariae whereas skin test reactivity was lowest. The multiple logistic regression showed that the risk of a positive skin test was 8-fold higher with increasing levels of mite-specific IgE but was reduced by 72% when infected with blood stage helminths. Conclusions: Chronic blood and tissue parasite infections that are often capable of modulating immune responses in the host are negatively associated with skin test reactivity in a sensitized population.

© 2001 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: December 14, 2001
Issue release date: November 2001

Number of Print Pages: 8
Number of Figures: 1
Number of Tables: 4

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA


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