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Table of Contents
Vol. 40, No. 3, 2001
Issue release date: September 2001
Section title: Kidney Cancer
Eur Urol 2001;40:330–336
(DOI:10.1159/000049795)

Familial and Sporadic Renal Oncocytomas – A Comparative Molecular–Genetic Analysis

Junker K.a · Weirich G.b,d · Moravek P.e · Podhola M.f · Ilse B.a · Hartmann A.c · Schubert J.a
aDepartment of Urology, Jena, bInstitute of Pathology, Technische Universität, Munich, and cInstitute of Pathology, Regensburg, Germany; dLIB, National Cancer Institute – FCRDC, Frederick, Md., USA; eDepartment of Urology and fInstitute of Pathology, Charles University, Hradec Kralove, Czech Republic

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Article / Publication Details

First-Page Preview
Abstract of Kidney Cancer

Published online: October 29, 2001
Issue release date: September 2001

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 2

ISSN: 0302-2838 (Print)
eISSN: 1421-993X (Online)

For additional information: http://www.karger.com/EUR

Abstract

Objectives: Genetic causes of sporadic and familial renal oncocytomas are not known. We analyzed these tumors genetically in order to detect tumor–specific chromosome alterations. Methods: DNA from 26 sporadic and 31 familial renal oncocytomas were screened by comparative genomic hybridization according to standard protocols including degenerate oligonucleotide–primed PCR. Results: Chromosome alterations were detected in 19/26 sporadic (73%) and in 4/31 familial renal oncocytomas (13%). Partial or complete losses of chromosome 1 were most frequently found in both sporadic (15/26) and familial tumors (2/4). Less frequently, loss of chromosome 14 (3/26) was detected in sporadic renal oncocytomas as well as losses of 2p, 2q, 4q, 10 and 18 and gains of 1q and 17q in individual sporadic tumors. Inter–tumor variation of chromosome aberrations was prominent in 1 patient, where 1 tumor showed gains of chromosomes 5, 6q, 7, 10p, 12 and 13q, whereas the second tumor exhibited gains of chromosomes 5 and 7 and loss of 10q. In contrast to sporadic renal oncocytomas, most familial tumors (87%) were devoid of chromosome instabilities. Conclusion: Our results demonstrate that partial or complete loss of chromosome 1 is the most common alteration in renal oncocytomas, sporadic and familial. However, chromosome changes are much rarer in familial than in sporadic renal oncocytomas.


Article / Publication Details

First-Page Preview
Abstract of Kidney Cancer

Published online: October 29, 2001
Issue release date: September 2001

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 2

ISSN: 0302-2838 (Print)
eISSN: 1421-993X (Online)

For additional information: http://www.karger.com/EUR


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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.