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Table of Contents
Vol. 44, No. 4, 2001
Issue release date: July – August
Section title: Original Paper
Intervirology 2001;44:215–218
(DOI:10.1159/000050049)

Hepatitis C Virus and GBV-C/Hepatitis G Virus in Argentine Patients with Porphyria Cutanea Tarda

Oubiña J.R.a · Quarleri J.F.a · Sawicki M.A.b · Mathet V.L.a · Ruiz V.a · Schroder T.b · Méndez M.c · Parera V.c · Muramatsu H.c · Battle A.c · González Cappa S.M.a · Fainboim H.A.b
aDepartment of Microbiology, Faculty of Medicine, University of Buenos Aires, bCIPYP Buenos Aires, and cHepatology Unit, Muñiz Hospital, Buenos Aires, Argentina

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: August 17, 2001
Issue release date: July – August

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 1

ISSN: 0300-5526 (Print)
eISSN: 1423-0100 (Online)

For additional information: http://www.karger.com/INT

Abstract

To investigate hepatitis C virus (HCV) and GBV-C/hepatitis G virus (HGV) genotype prevalence among HCV-infected porphyria cutanea tarda (PCT) patients, 19 HCV-infected patients with associated PCT were studied. A control group of 53 age-matched HCV-infected patients without associated PCT was selected. Eighteen of the 19 serologically positive HCV-PCT patients showed HCV RNA in serum. Genotype 1b was the most prevalent among both HCV-PCT patients (72.2%; 13/18) and age-matched HCV controls (50.9%; 27/53). Such different genotypic prevalence failed to reach statistical significance (χ2 with Yates’ correction, p = 0.19). The single HCV-PCT patient without detectable HCV RNA was also infected with genogroup 3 GBV-C/HGV. This GBV-C/HGV RNA prevalence (5.3%) among HCV-PCT patients is not statistically different from that observed among Argentine blood donors (5.5%; 11/200). To our knowledge, these results show for the first time the molecular epidemiology of both HCV and GBV-C/HGV associated to PCT in America.

© 2001 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: August 17, 2001
Issue release date: July – August

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 1

ISSN: 0300-5526 (Print)
eISSN: 1423-0100 (Online)

For additional information: http://www.karger.com/INT


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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