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Table of Contents
Vol. 44, No. 6, 2001
Issue release date: January 2002
Section title: Short Communication
Intervirology 2001;44:379–382
(DOI:10.1159/000050075)

Genetic Polymorphism of the MxA Gene Promoter and Interferon Responsiveness of Hepatitis C Patients: Revisited by Analyzing Two SNP Sites (–123 and –88) in vivo and in vitro

Hijikata M.a · Mishiro S.a · Miyamoto C.b · Furuichi Y.b,c · Hashimoto M.a,d · Ohta Y.e
aDepartment of Medical Sciences, Toshiba General Hospital, Tokyo, bAgene Research Institute, Kamakura, cThe GeneCare Institute, Kamakura, dResearch and Development Center of Toshiba, Kawasaki, and eDepartment of Gastroenterology, Toshiba General Hospital, Tokyo, Japan

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Article / Publication Details

First-Page Preview
Abstract of Short Communication

Published online: January 18, 2002
Issue release date: January 2002

Number of Print Pages: 4
Number of Figures: 2
Number of Tables: 3

ISSN: 0300-5526 (Print)
eISSN: 1423-0100 (Online)

For additional information: http://www.karger.com/INT

Abstract

We have previously reported a single nucleotide polymorphism (SNP) at nucleotide (nt) position –88 (G or T) within an interferon-stimulated response element-like sequence in the promoter region of the MxA gene, which correlated with responsiveness of hepatitis C patients to interferon. Upstream of it, we then identified another SNP (C or A at nt –123) and investigated whether this SNP also correlates with interferon responsiveness. The two SNPs showed a high linkage to each other: all the individuals having G at –88 had C at –123, and 73% of those having T at –88 had A at –123. As was expected from this observation, the SNP at –123 also exhibited a correlation with interferon responsiveness (C/C homozygotes were more frequent among nonresponders than among responders: 65% of 107 vs. 40% of 52, p = 0.0028). These in vivo data from patients were further supported by results from in vitro experiments. The MxA promoter sequence with A at –123 and T at –88 showed about 4-fold higher activity of upregulating the downstream reporter gene than that with C at –123 and G at –88, in a luciferase reporter assay.

© 2002 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Short Communication

Published online: January 18, 2002
Issue release date: January 2002

Number of Print Pages: 4
Number of Figures: 2
Number of Tables: 3

ISSN: 0300-5526 (Print)
eISSN: 1423-0100 (Online)

For additional information: http://www.karger.com/INT


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