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Vol. 68, No. 5, 2001
Issue release date: September–October 2001
Section title: Clinical Investigations
Respiration 2001;68:496–500
(DOI:10.1159/000050557)

Serum Levels of Vascular Endothelial Growth Factor and Cavity Formation in Active Pulmonary Tuberculosis

Abe Y. · Nakamura M. · Oshika Y. · Hatanaka H. · Tokunaga T. · Ohkubo Y. · Hashizume T. · Suzuki K. · Fujino T.
aDepartment of Respiratory Disease, National Sanatorium Kanagawa Hospital, Hadano, bDepartment of Pathology, Tokai University School of Medicine, Isehara, Japan

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Article / Publication Details

First-Page Preview
Abstract of Clinical Investigations

Published online: 10/26/2001

Number of Print Pages: 5
Number of Figures: 2
Number of Tables: 1

ISSN: 0025-7931 (Print)
eISSN: 1423-0356 (Online)

For additional information: http://www.karger.com/RES

Abstract

Background: In active pulmonary tuberculosis, certain cytokines have been postulated to be related to cavity formation, although the detailed mechanism of cavity formation is not yet known. Objective: We examined the relationship between cavity formation in pulmonary tuberculosis and vascular endothelial growth factor (VEGF), which functions as an angiogenesis factor. Methods: Forty-eight patients with active pulmonary tuberculosis were divided into two groups according to cavity formation as evaluated by chest high-resolution computed tomography. We evaluated serum VEGF levels by enzyme immunoassay. Results: Group A (with cavities) was comprised of 22 patients and group B (without cavities) was comprised of 26 patients. The serum levels of VEGF were significantly higher in group B (58.733 ± 21.612 pg/ml) than those in normal individuals (8.739 ± 3.656 pg/ml) and in group A (13.053 ± 8.670 pg/ml) (Mann-Whitney U test, p = 0.0149 and p = 0.0481, respectively). Serum levels of interleukin-8 and tumor necrosis factor-α were not significantly different between the two groups. Conclusion: These findings suggested that increased serum VEGF levels subdue cavity formation in active pulmonary tuberculosis.


  

Author Contacts

Yoshiyuki Abe, MD
Department of Respiratory Disease
National Sanatorium Kanagawa Hospital
666-1, Ochiai, Hadano, Kanagawa 257-8585 (Japan)
Tel. +81 463 81 1771, Fax +81 463 82 7533, E-Mail abey@kanagawa.hosp.go.jp

  

Article Information

Received: Received: July 3, 2000
Accepted after revision: March 7, 2001
Number of Print Pages : 5
Number of Figures : 2, Number of Tables : 1, Number of References : 26

  

Publication Details

Respiration (International Review of Thoracic Diseases)
Founded 1944 as ‘Schweizerische Zeitschrift für Tuberkulose und Pneumonologie’ by E. Bachmann, M. Gilbert, F. Häberlin, W. Löffler, P. Steiner and E. Uehlinger, continued 1962–1967 as ‘Medicina Thoracalis’

Vol. 68, No. 5, Year 2001 (Cover Date: September-October 2001)

Journal Editor: C.T. Bolliger, Cape Town
ISSN: 0025–7931 (print), 1423–0356 (Online)

For additional information: http://www.karger.com/journals/res


Article / Publication Details

First-Page Preview
Abstract of Clinical Investigations

Published online: 10/26/2001

Number of Print Pages: 5
Number of Figures: 2
Number of Tables: 1

ISSN: 0025-7931 (Print)
eISSN: 1423-0356 (Online)

For additional information: http://www.karger.com/RES


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