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Vol. 68, No. 6, 2001
Issue release date: November–December 2001
Section title: Clinical Investigations
Respiration 2001;68:566–572
(DOI:10.1159/000050574)

Daytime Pulmonary Hypertension in Patients with Obstructive Sleep Apnea

The Effect of Continuous Positive Airway Pressure on Pulmonary Hemodynamics

Alchanatis M.a · Tourkohoriti G.a · Kakouros S.b · Kosmas E.a · Podaras S.a · Jordanoglou J.B.a
aPulmonary Department, Athens University Medical School and bCardiology Department, ‘Sotiria’ Hospital for Chest Diseases, Athens, Greece

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Article / Publication Details

First-Page Preview
Abstract of Clinical Investigations

Published online: 12/21/2001
Issue release date: November–December 2001

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 3

ISSN: 0025-7931 (Print)
eISSN: 1423-0356 (Online)

For additional information: http://www.karger.com/RES

Abstract

Background: Limited information exists regarding the development of pulmonary hypertension in patients with obstructive sleep apnea (OSA) in the absence of lung and heart comorbidity. Objectives: The aims of this study were to investigate whether OSA patients without any other cardiac or lung disease develop pulmonary hypertension, and to assess the effect of continuous positive airway pressure (CPAP) treatment on pulmonary artery pressure (PPA). Methods: Twenty-nine patients aged 51 ± 10 years with OSA and 12 control subjects were studied with pulsed-wave Doppler echocardiography for estimation of PPA before and after 6-month effective treatment with CPAP. Results: A significantly higher mean PPA was found in OSA patients as compared to control subjects (17.2 ± 5.2 vs. 12.1 ± 1.9 mm Hg, p < 0.001). Six out of the 29 OSA patients had mild pulmonary hypertension (PPA ≧ 20 mm Hg). Significant differences were observed between pulmonary hypertensive and normotensive OSA patients with respect to age (62 ± 4 vs. 48 ± 15 years, respectively, p < 0.05), body mass index (41 ± 7 vs. 32 ± 4 kg/m2, p < 0.02) and daytime PaO2 (81 ± 9 vs. 92 ± 9 mm Hg, p < 0.05). CPAP treatment was effective in reducing mean PPA in both groups of pulmonary hypertensive and normotensive OSA patients (decreases in PPA from 25.6 ± 4.0 to 19.5 ± 1.5 mm Hg, p < 0.001; from 14.9 ± 2.2 to 11.5 ± 2.0 mm Hg, respectively, p < 0.001). Conclusions: A proportion (20.7%) of OSA patients without any other lung or heart disease and characterized by older age, greater obesity and lower daytime oxygenation develop mild pulmonary hypertension which has been partially or completely reversed after 6-month CPAP treatment. In conclusion, OSA alone constitutes an independent risk factor for the development of pulmonary hypertension.

© 2001 S. Karger AG, Basel


  

Author Contacts

Manos Alchanatis, MD
Assoc. Professor
10 Mpakopoulou Str.
GR–15451 Athens (Greece)
Tel. +30 1 7774163, Fax +30 1 7770423

  

Article Information

Received: Received: February 5, 2001
Accepted after revision: May 29, 2001
Number of Print Pages : 7
Number of Figures : 3, Number of Tables : 3, Number of References : 21

  

Publication Details

Respiration (International Review of Thoracic Diseases)
Founded 1944 as ‘Schweizerische Zeitschrift für Tuberkulose und Pneumonologie’ by E. Bachmann, M. Gilbert, F. Häberlin, W. Löffler, P. Steiner and E. Uehlinger, continued 1962–1967 as ‘Medicina Thoracalis’

Vol. 68, No. 6, Year 2001 (Cover Date: November-December 2001)

Journal Editor: C.T. Bolliger, Cape Town
ISSN: 0025–7931 (print), 1423–0356 (Online)

For additional information: http://www.karger.com/journals/res


Article / Publication Details

First-Page Preview
Abstract of Clinical Investigations

Published online: 12/21/2001
Issue release date: November–December 2001

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 3

ISSN: 0025-7931 (Print)
eISSN: 1423-0356 (Online)

For additional information: http://www.karger.com/RES


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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