Experimental Animal Models in Pancreatic Carcinogenesis: Lessons for Human Pancreatic CancerStandop J. · Schneider M.B. · Ulrich A. · Pour P.M.
aUNMC Eppley Cancer Center, University of Nebraska Medical Center, Omaha, Nebr., USA; bDepartment of Surgery, Rheinische Friedrich-Wilhelms-Universität, Bonn, Germany; cDepartment of Visceral and Transplantation Surgery, Inselspital Bern, Switzerland; dDepartment of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebr., USA
The silent course of pancreatic cancer and its explosive fatal outcome have hindered studies of tumor histogenesis and the identification of early biochemical and genetic alterations that could help to diagnose the disease at a curable stage and develop therapeutic strategies. Experimental animal models provide important tools to assess risk factors, as well as preventive and therapeutic possibilities. Although several pancreatic cancer models presently exist, only models that closely resemble human tumors in morphological, clinical, and biological aspects present useful media for preclinical studies. Because an estimated 70% of human tumors are induced by carcinogens and because a significant association has been found between cigarette smoking and pancreatic cancer, chemically induced models are of particular value. Moreover, in such models the etiology, modifying factors, effects of diets, and naturally occurring products can be studied and early diagnostic, preventive, and therapeutic possibilities sought out. Many of the existing models are described in this review, and the advantages and shortcomings of each model and their clinical implications are discussed.
Parviz M. Pour, MD
Eppley Institute for Research in Cancer and Allied Diseases
University of Nebraska Medical Center
Omaha, NE 68198-6805 (USA)
Tel. +1 402 559 4495, Fax +1 402 559 4651, E-Mail email@example.com
Number of Print Pages : 8
Number of Figures : 0, Number of Tables : 0, Number of References : 89
Digestive Diseases (Clinical Reviews)
Formerly ‘Survey of Digestive Diseases’; Founded in 1983 by T.S.N. Chen and R.K. Zetterman
Vol. 19, No. 1, Year 2001 (Cover Date: 2001)
Journal Editor: P. Malfertheiner, Magdeburg
ISSN: 0257–2753 (print), 1421–9875 (Online)
For additional information: http://www.karger.com/journals/ddi