Circulating Leptin Levels and Weight Loss in Alzheimer’s Disease PatientsPower D.A. · Noel J. · Collins R. · O’Neill D.
aDepartment of Clinical Geratology, Radcliffe Infirmary, Oxford, UK; bDepartment of Medicine for the Elderly, Mater Misericordiae Hospital, and cDepartment of Age-Related Health Care, Adeleaide, Meath and National Childrens Hospital, Tallaght, Dublin, Ireland
Weight loss is common in Alzheimer’s disease (AD) and is predictive of mortality. Leptin, an adipocyte-derived peptide hormone is implicated in the regulation of satiety and energy expenditure. It acts on the hypothalamus to suppress appetite and increase energy expenditure. We undertook this study to determine if inappropriately elevated leptin levels play a role in AD-associated weight loss. Serum leptin levels of 8 patients in each of the following groups were determined: (1) AD, body mass index (BMI) >25; (2) AD, BMI <20; (3) non-Alzheimer’s (vascular) dementia (VaD), BMI >25, and (4) VaD, BMI <20. Mean serum leptin levels were significantly lower in below-appropriate-weight patients (both AD and VaD) than in appropriate-weight controls. Below-appropriate-weight AD patients had a significantly lower mean serum leptin concentration than appropriate-weight VaD controls. Weight loss is a feature of AD. Inappropriately elevated leptin levels do not appear to be implicated. Indeed, we have shown that the afferent limb of the leptin feedback loop is intact in below-appropriate-weight AD patients and suggest hypothalamic dysfunction may underlie this feature.
Dr. Dermot Power
Department of Clinical Geratology
Radcliffe Infirmary, Woodstock Road
Oxford, OX2 6HE (UK)
Tel. +44 1865 311188, Fax +44 1865 224815, E-Mail firstname.lastname@example.org
Received: Accepted: August 8, 2000
Number of Print Pages : 4
Number of Figures : 2, Number of Tables : 2, Number of References : 14
Dementia and Geriatric Cognitive Disorders
Vol. 12, No. 2, Year 2001 (Cover Date: March-April 2001)
Journal Editor: V. Chan-Palay, New York, N.Y.
ISSN: 1420–8008 (print), 1421–9824 (Online)
For additional information: http://www.karger.com/journals/dem