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Vol. 12, No. 2, 2001
Issue release date: March–April 2001
Section title: Original Research Article
Dement Geriatr Cogn Disord 2001;12:167–170
(DOI:10.1159/000051252)

Circulating Leptin Levels and Weight Loss in Alzheimer’s Disease Patients

Power D.A. · Noel J. · Collins R. · O’Neill D.
aDepartment of Clinical Geratology, Radcliffe Infirmary, Oxford, UK; bDepartment of Medicine for the Elderly, Mater Misericordiae Hospital, and cDepartment of Age-Related Health Care, Adeleaide, Meath and National Childrens Hospital, Tallaght, Dublin, Ireland

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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Published online: 2/9/2001

Number of Print Pages: 4
Number of Figures: 2
Number of Tables: 2

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM

Abstract

Weight loss is common in Alzheimer’s disease (AD) and is predictive of mortality. Leptin, an adipocyte-derived peptide hormone is implicated in the regulation of satiety and energy expenditure. It acts on the hypothalamus to suppress appetite and increase energy expenditure. We undertook this study to determine if inappropriately elevated leptin levels play a role in AD-associated weight loss. Serum leptin levels of 8 patients in each of the following groups were determined: (1) AD, body mass index (BMI) >25; (2) AD, BMI <20; (3) non-Alzheimer’s (vascular) dementia (VaD), BMI >25, and (4) VaD, BMI <20. Mean serum leptin levels were significantly lower in below-appropriate-weight patients (both AD and VaD) than in appropriate-weight controls. Below-appropriate-weight AD patients had a significantly lower mean serum leptin concentration than appropriate-weight VaD controls. Weight loss is a feature of AD. Inappropriately elevated leptin levels do not appear to be implicated. Indeed, we have shown that the afferent limb of the leptin feedback loop is intact in below-appropriate-weight AD patients and suggest hypothalamic dysfunction may underlie this feature.


  

Author Contacts

Dr. Dermot Power
Department of Clinical Geratology
Radcliffe Infirmary, Woodstock Road
Oxford, OX2 6HE (UK)
Tel. +44 1865 311188, Fax +44 1865 224815, E-Mail dermot_power@hotmail.com

  

Article Information

Received: Accepted: August 8, 2000
Number of Print Pages : 4
Number of Figures : 2, Number of Tables : 2, Number of References : 14

  

Publication Details

Dementia and Geriatric Cognitive Disorders

Vol. 12, No. 2, Year 2001 (Cover Date: March-April 2001)

Journal Editor: V. Chan-Palay, New York, N.Y.
ISSN: 1420–8008 (print), 1421–9824 (Online)

For additional information: http://www.karger.com/journals/dem


Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Published online: 2/9/2001

Number of Print Pages: 4
Number of Figures: 2
Number of Tables: 2

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM


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