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Vol. 199, Suppl. 1, 1999
Issue release date: 1999
Section title: Paper
Dermatology 1999;199(suppl 1):53–56
(DOI:10.1159/000051380)

Retinaldehyde Alleviates Rosacea

Vienne M.-P. · Ochando N. · Borrel M.-T. · Gall Y. · Lauze C. · Dupuy P.
aDepartment of Clinical Research and bJean-Louis Alibert Center, Pierre Fabre Research Institute, Toulouse, France

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 8/12/1999
Issue release date: 1999

Number of Print Pages: 4
Number of Figures: 2
Number of Tables: 1

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: http://www.karger.com/DRM

Abstract

Background: Anecdotal observations suggest that retinoic acid may be effective in mild rosacea. Aim: Our aim was to investigate, by an exploratory clinical and instrumental study, the effects of a topical formulation with the retinoic acid precursor retinaldehyde, in patients with vascular signs of facial rosacea. Methods: Female patients were treated with a 0.05% retinaldehyde cream that was applied once daily for 6 months. Clinical assessments of persistent erythema and telangiectasia were performed every month, using a 4-point severity score (absent to severe). The clinical response for each parameter was defined as a decrease of at least 1 grade in the severity score. In addition, erythema was further evaluated by measurement of the a* parameter, using a spectrophotometer on lesional and nonlesional areas. Results: A total of 23 women comprised the study population. At baseline, 10 patients had diffuse erythema, 3 patients had isolated telangiectasia and 10 patients had both. During retinaldehyde treatment, a clinical response was revealed in about 75% of the patients with erythema, after 5 months (p < 0.05). Similarly, isolated telangiectasia responded to retinaldehyde, although to a lesser extent and after a longer period of treatment (46% responders after 6 months, nonsignificant). Using the spectrophotometer, the a* parameter diminished in patients with erythema by about 15%, after 2 months of treatment (p = 0.001). Conclusion: This study indicates that retinaldehyde has beneficial effects on the vascular component of rosacea.


  

Author Contacts

Patrick Dupuy, MD
Pierre Fabre Research Institute, Allée Camille-Soula, BP 74, Vigoulet Auzil
F–31322 Castanet Tolosan Cedex (France)
Tel. +33 5 61 75 52 85, Fax +33 5 61 75 52 52
E-Mail patrick.dupuy@pierre-fabre.com

  

Article Information

Number of Print Pages : 4
Number of Figures : 2, Number of Tables : 1, Number of References : 7

  

Publication Details

Dermatology (International Journal for Clinical and Investigative Dermatology)
Founded as ‘Dermatologische Zeitschrift’ by Oskar Lassar (1893–1907); Continued by Erich Hoffmann (1908–1938), continued as ‘Dermatologica’ (1939–1991), by Wilhelm Lutz (1939–1958), Rudolf Schuppli (1959–1985)
Official Organ of the Swiss Society for Dermatology and Venereology; Official Organ of the Belgian Royal Society for Dermatology and Venereology

Vol. 199, No. Suppl. 1, Year 1999 (Cover Date: 1999)

Journal Editor: J.-H. Saurat, Geneva.
ISSN: 1018–8665 (print), 1421–9832 (Online)

For additional information: http://www.karger.com/journals/drm


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 8/12/1999
Issue release date: 1999

Number of Print Pages: 4
Number of Figures: 2
Number of Tables: 1

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: http://www.karger.com/DRM


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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