Treatment of Refractory Atopic Dermatitis Using ‘Wet-Wrap’ Dressings and Diluted Corticosteroids: Results of Standardized Treatment in both Children and AdultsDevillers A.C.A. · de Waard-van der Spek F.B. · Mulder P.G.H. · Oranje A.P.
aDepartment of Dermatology and Venereology, University Hospital Rotterdam, and bDepartment of Epidemiology and Biostatistics, Erasmus University Rotterdam, The Netherlands
Background: ‘Wet-wrap’ dressings with diluted corticosteroids form an alternative treatment in patients with refractory atopic dermatitis (AD). Objective: To evaluate a standardized treatment, using wet-wrap dressings with diluted corticosteroids, in patients with refractory AD. Methods: Results of treatment, complications and possible side effects were retrospectively evaluated in 14 children and 12 adults. Results: Skin lesions improved dramatically during 1 week of inpatient treatment. A significant decrease in early-morning serum cortisol levels was measured. Levels below the normal range were only observed after 1 week in 2 adults and on day 4 in 3 children. Suppression of the hypothalamus-pituitary-adrenal-cortex axis in 1 adult and a new exacerbation of AD in 2 children and 3 adults complicated long-term treatment at home. Additional complications included folliculitis, a Pseudomonas aeruginosa infection, a secondary bacterial infection and refractory skin lesions between bandages. Conclusion: Wet-wrap dressings and diluted corticosteroids form an effective treatment in patients with refractory AD.
University Hospital Rotterdam, Department of Dermatology and Venereology
Dr. Molewaterplein 40, PO Box 2040
NL–3000 CA Rotterdam (The Netherlands)
Tel. +31 10 4636656, Fax +31 10 4636707, E-Mail firstname.lastname@example.org
Received: Received: March 23, 2001
Accepted: July 17, 2001
Number of Print Pages : 6
Number of Figures : 3, Number of Tables : 4, Number of References : 21
Dermatology (International Journal for Clinical and Investigative Dermatology)
Founded as ‘Dermatologische Zeitschrift’ by Oskar Lassar (1893–1907); Continued by Erich Hoffmann (1908–1938), continued as ‘Dermatologica’ (1939–1991), by Wilhelm Lutz (1939–1958), Rudolf Schuppli (1959–1985)
Official Organ of the Swiss Society for Dermatology and Venereology; Official Organ of the Belgian Royal Society for Dermatology and Venereology
Vol. 204, No. 1, Year 2002 (Cover Date: 2002)
Journal Editor: J.-H. Saurat, Geneva.
ISSN: 1018–8665 (print), 1421–9832 (Online)
For additional information: http://www.karger.com/journals/drm