Treatment of Refractory Atopic Dermatitis Using ‘Wet-Wrap’ Dressings and Diluted Corticosteroids: Results of Standardized Treatment in both Children and AdultsDevillers A.C.A.a · de Waard-van der Spek F.B.a · Mulder P.G.H.b · Oranje A.P.a
aDepartment of Dermatology and Venereology, University Hospital Rotterdam, and bDepartment of Epidemiology and Biostatistics, Erasmus University Rotterdam, The Netherlands
Background: ‘Wet-wrap’ dressings with diluted corticosteroids form an alternative treatment in patients with refractory atopic dermatitis (AD). Objective: To evaluate a standardized treatment, using wet-wrap dressings with diluted corticosteroids, in patients with refractory AD. Methods: Results of treatment, complications and possible side effects were retrospectively evaluated in 14 children and 12 adults. Results: Skin lesions improved dramatically during 1 week of inpatient treatment. A significant decrease in early-morning serum cortisol levels was measured. Levels below the normal range were only observed after 1 week in 2 adults and on day 4 in 3 children. Suppression of the hypothalamus-pituitary-adrenal-cortex axis in 1 adult and a new exacerbation of AD in 2 children and 3 adults complicated long-term treatment at home. Additional complications included folliculitis, a Pseudomonas aeruginosa infection, a secondary bacterial infection and refractory skin lesions between bandages. Conclusion: Wet-wrap dressings and diluted corticosteroids form an effective treatment in patients with refractory AD.
© 2002 S. Karger AG, Basel
Received: Received: March 23, 2001
Accepted: July 17, 2001
Number of Print Pages : 6
Number of Figures : 3, Number of Tables : 4, Number of References : 21
Dermatology (International Journal for Clinical and Investigative Dermatology)
Founded as ‘Dermatologische Zeitschrift’ by Oskar Lassar (1893–1907); Continued by Erich Hoffmann (1908–1938), continued as ‘Dermatologica’ (1939–1991), by Wilhelm Lutz (1939–1958), Rudolf Schuppli (1959–1985)
Official Organ of the Swiss Society for Dermatology and Venereology; Official Organ of the Belgian Royal Society for Dermatology and Venereology
Vol. 204, No. 1, Year 2002 (Cover Date: 2002)
Journal Editor: J.-H. Saurat, Geneva.
ISSN: 1018–8665 (print), 1421–9832 (Online)
For additional information: http://www.karger.com/journals/drm