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Vol. 204, No. 1, 2002
Issue release date: 2002
Section title: Pharmacology and Treatment
Dermatology 2002;204:50–55
(DOI:10.1159/000051810)

Treatment of Refractory Atopic Dermatitis Using ‘Wet-Wrap’ Dressings and Diluted Corticosteroids: Results of Standardized Treatment in both Children and Adults

Devillers A.C.A.a · de Waard-van der Spek F.B.a · Mulder P.G.H.b · Oranje A.P.a
aDepartment of Dermatology and Venereology, University Hospital Rotterdam, and bDepartment of Epidemiology and Biostatistics, Erasmus University Rotterdam, The Netherlands

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Article / Publication Details

First-Page Preview
Abstract of Pharmacology and Treatment

Published online: 4/12/2002
Issue release date: 2002

Number of Print Pages: 6
Number of Figures: 3
Number of Tables: 4

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: http://www.karger.com/DRM

Abstract

Background: ‘Wet-wrap’ dressings with diluted corticosteroids form an alternative treatment in patients with refractory atopic dermatitis (AD). Objective: To evaluate a standardized treatment, using wet-wrap dressings with diluted corticosteroids, in patients with refractory AD. Methods: Results of treatment, complications and possible side effects were retrospectively evaluated in 14 children and 12 adults. Results: Skin lesions improved dramatically during 1 week of inpatient treatment. A significant decrease in early-morning serum cortisol levels was measured. Levels below the normal range were only observed after 1 week in 2 adults and on day 4 in 3 children. Suppression of the hypothalamus-pituitary-adrenal-cortex axis in 1 adult and a new exacerbation of AD in 2 children and 3 adults complicated long-term treatment at home. Additional complications included folliculitis, a Pseudomonas aeruginosa infection, a secondary bacterial infection and refractory skin lesions between bandages. Conclusion: Wet-wrap dressings and diluted corticosteroids form an effective treatment in patients with refractory AD.

© 2002 S. Karger AG, Basel


  

Article Information

Received: Received: March 23, 2001
Accepted: July 17, 2001
Number of Print Pages : 6
Number of Figures : 3, Number of Tables : 4, Number of References : 21

  

Publication Details

Dermatology (International Journal for Clinical and Investigative Dermatology)
Founded as ‘Dermatologische Zeitschrift’ by Oskar Lassar (1893–1907); Continued by Erich Hoffmann (1908–1938), continued as ‘Dermatologica’ (1939–1991), by Wilhelm Lutz (1939–1958), Rudolf Schuppli (1959–1985)
Official Organ of the Swiss Society for Dermatology and Venereology; Official Organ of the Belgian Royal Society for Dermatology and Venereology

Vol. 204, No. 1, Year 2002 (Cover Date: 2002)

Journal Editor: J.-H. Saurat, Geneva.
ISSN: 1018–8665 (print), 1421–9832 (Online)

For additional information: http://www.karger.com/journals/drm


Article / Publication Details

First-Page Preview
Abstract of Pharmacology and Treatment

Published online: 4/12/2002
Issue release date: 2002

Number of Print Pages: 6
Number of Figures: 3
Number of Tables: 4

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: http://www.karger.com/DRM


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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