Topical Steroids under Wet-Wrap Dressings in Atopic Dermatitis – A Vehicle-Controlled TrialSchnopp C. · Holtmann C. · Stock S. · Remling R. · Fölster-Holst R. · Ring J. · Abeck D.
Department of Dermatology and Allergy am Biederstein, Technical University of Munich, Germany
Background: The wet-wrap dressing technique has proved to be beneficial in cases of exacerbated atopic dermatitis (AD) skin lesions. Objective: The effect of wet-wrap dressings was investigated in a controlled trial comparing a steroid (mometasone furoate 0.1%)-containing and a steroid-free (vehicle) preparation in an in-patient comparison study. Methods: 20 children aged 2–17 years with exacerbated AD were treated twice daily with wet-wrap dressings over a 5-day period. Results: AD in treated areas significantly improved in both study arms; however, the effect was significantly better in the mometasone-treated group (p < 0.01). Transepidermal water loss improved in both arms without any significant differences. Staphylococcus aureus colonization decreased during the first 3 days of active treatment independently of the therapeutic modalities chosen. At day 5, colony counts further dropped on the steroid-treated lesions. Conclusion: Application of the wet-wrap dressing technique for exacerbated AD lesions is effective, combination with a topical steroid being superior to a steroid-free application without bearing the risk of a bacterial superinfection.
© 2002 S. Karger AG, Basel
Christina Schnopp, MD
Klinik und Poliklinik für Dermatologie und Allergologie am Biederstein
Technische Universität München, Biedersteiner Strasse 29
D–80802 München (Germany)
Tel. +49 89 4140 3235, Fax +49 89 4140 3502, E-Mail email@example.com
Received: Received: March 3, 2001
Accepted: August 23, 2001
Number of Print Pages : 4
Number of Figures : 2, Number of Tables : 2, Number of References : 15
Dermatology (International Journal for Clinical and Investigative Dermatology)
Founded as ‘Dermatologische Zeitschrift’ by Oskar Lassar (1893–1907); Continued by Erich Hoffmann (1908–1938), continued as ‘Dermatologica’ (1939–1991), by Wilhelm Lutz (1939–1958), Rudolf Schuppli (1959–1985)
Official Organ of the Swiss Society for Dermatology and Venereology; Official Organ of the Belgian Royal Society for Dermatology and Venereology
Vol. 204, No. 1, Year 2002 (Cover Date: 2002)
Journal Editor: J.-H. Saurat, Geneva.
ISSN: 1018–8665 (print), 1421–9832 (Online)
For additional information: http://www.karger.com/journals/drm