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Vol. 204, No. 1, 2002
Issue release date: 2002
Section title: Pharmacology and Treatment
Dermatology 2002;204:56–59
(DOI:10.1159/000051811)

Topical Steroids under Wet-Wrap Dressings in Atopic Dermatitis – A Vehicle-Controlled Trial

Schnopp C. · Holtmann C. · Stock S. · Remling R. · Fölster-Holst R. · Ring J. · Abeck D.
Department of Dermatology and Allergy am Biederstein, Technical University of Munich, Germany

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Article / Publication Details

First-Page Preview
Abstract of Pharmacology and Treatment

Published online: 4/12/2002
Issue release date: 2002

Number of Print Pages: 4
Number of Figures: 2
Number of Tables: 2

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: http://www.karger.com/DRM

Abstract

Background: The wet-wrap dressing technique has proved to be beneficial in cases of exacerbated atopic dermatitis (AD) skin lesions. Objective: The effect of wet-wrap dressings was investigated in a controlled trial comparing a steroid (mometasone furoate 0.1%)-containing and a steroid-free (vehicle) preparation in an in-patient comparison study. Methods: 20 children aged 2–17 years with exacerbated AD were treated twice daily with wet-wrap dressings over a 5-day period. Results: AD in treated areas significantly improved in both study arms; however, the effect was significantly better in the mometasone-treated group (p < 0.01). Transepidermal water loss improved in both arms without any significant differences. Staphylococcus aureus colonization decreased during the first 3 days of active treatment independently of the therapeutic modalities chosen. At day 5, colony counts further dropped on the steroid-treated lesions. Conclusion: Application of the wet-wrap dressing technique for exacerbated AD lesions is effective, combination with a topical steroid being superior to a steroid-free application without bearing the risk of a bacterial superinfection.

© 2002 S. Karger AG, Basel


  

Author Contacts

Christina Schnopp, MD
Klinik und Poliklinik für Dermatologie und Allergologie am Biederstein
Technische Universität München, Biedersteiner Strasse 29
D–80802 München (Germany)
Tel. +49 89 4140 3235, Fax +49 89 4140 3502, E-Mail nina.schnopp@lrz-tu-muenchen.de

  

Article Information

Received: Received: March 3, 2001
Accepted: August 23, 2001
Number of Print Pages : 4
Number of Figures : 2, Number of Tables : 2, Number of References : 15

  

Publication Details

Dermatology (International Journal for Clinical and Investigative Dermatology)
Founded as ‘Dermatologische Zeitschrift’ by Oskar Lassar (1893–1907); Continued by Erich Hoffmann (1908–1938), continued as ‘Dermatologica’ (1939–1991), by Wilhelm Lutz (1939–1958), Rudolf Schuppli (1959–1985)
Official Organ of the Swiss Society for Dermatology and Venereology; Official Organ of the Belgian Royal Society for Dermatology and Venereology

Vol. 204, No. 1, Year 2002 (Cover Date: 2002)

Journal Editor: J.-H. Saurat, Geneva.
ISSN: 1018–8665 (print), 1421–9832 (Online)

For additional information: http://www.karger.com/journals/drm


Article / Publication Details

First-Page Preview
Abstract of Pharmacology and Treatment

Published online: 4/12/2002
Issue release date: 2002

Number of Print Pages: 4
Number of Figures: 2
Number of Tables: 2

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: http://www.karger.com/DRM


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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