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Vol. 63, No. 3, 2001
Issue release date: 2001
Section title: Original Paper: Esophageal Disorders
Digestion 2001;63:163–170
(DOI:10.1159/000051885)

Comparison of Pantoprazole 20 mg to Ranitidine 150 mg b.i.d. in the Treatment of Mild Gastroesophageal Reflux Disease

Kaspari S.a · Biedermann A.b · Mey J.c
aLüneburg; bBlankenhain, and cDortmund, Germany

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Article / Publication Details

First-Page Preview
Abstract of Original Paper: Esophageal Disorders

Published online: 5/9/2001
Issue release date: 2001

Number of Print Pages: 8
Number of Figures: 3
Number of Tables: 3

ISSN: 0012-2823 (Print)
eISSN: 1421-9867 (Online)

For additional information: http://www.karger.com/DIG

Abstract

Background: Despite a high prevalence of mild gastroesophageal reflux disease (GERD), few studies investigated efficacy and safety of proton pump inhibitors in this indication. This randomized double-blind study compares pantoprazole to ranitidine in GERD 0 and I, i.e. reflux without esophagitis or with confined lesions only. Methods: Patients received either pantoprazole 20 mg o.a.d. or ranitidine 150 mg b.i.d. Outcome was assessed after 2 and 4 weeks. Primary criterion was relief of leading symptoms, i.e. heartburn, acid eructation and pain on swallowing, after 4 weeks of treatment. Results: According to the per-protocol (PP) analysis, 69% (100/144) and 80% (115/144) of patients in the pantoprazole group were relieved of leading symptoms after 2 and 4 weeks, respectively. The rates in the ranitidine group were 47% (62/133) and 65% (86/133). Thus, superiority of pantoprazole could be proven. Quality-of-life parameters improved more in the pantoprazole group and patients’ assessment of treatment was more favorable. Analysis for Helicobacter pylori status showed infection to lead to higher symptom relief rates. Both study medications were well tolerated. Conclusion: Pantoprazole 20 mg demonstrated superior efficacy with faster relief of reflux symptoms and similar tolerability compared to ranitidine 150 mg in the treatment of mild GERD.

© 2001 S. Karger AG, Basel


  

Author Contacts

S. Kaspari
Haagestrasse 3
D–21335 Lüneburg (Germany)
Tel. +49 4131 49291, Fax +49 4131 45378

  

Article Information

Received: Received: March 6, 2000
Accepted: October 30, 2000
Number of Print Pages : 8
Number of Figures : 3, Number of Tables : 3, Number of References : 35

  

Publication Details

Digestion (International Journal of Gastroenterology)
Founded as Archiv für Verdauungskrankheiten, 1895; continued as Gastroenterologia, 1939-1967

Vol. 63, No. 3, Year 2001 (Cover Date: 2001)

Journal Editor: R. Arnold, Marburg
ISSN: 0012–2823 (print), 1421–9867 (Online)

For additional information: http://www.karger.com/journals/dig


Article / Publication Details

First-Page Preview
Abstract of Original Paper: Esophageal Disorders

Published online: 5/9/2001
Issue release date: 2001

Number of Print Pages: 8
Number of Figures: 3
Number of Tables: 3

ISSN: 0012-2823 (Print)
eISSN: 1421-9867 (Online)

For additional information: http://www.karger.com/DIG


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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