Malignant Peripheral Nerve Sheath Tumor of the EsophagusManger T. · Pross M. · Haeckel C. · Lippert H.
Departments of aSurgery and bPathology, Otto von Guericke University, Magdeburg, Germany
Background: Sarcomas of the esophagus are rare representing 0.1–1.5% of all esophageal tumors. We report a case of malignant peripheral nerve sheath tumor (MPNST) of the esophagus in a 60-year-old woman. Methods: The diagnosis was made preoperatively on endoscopic biopsy and confirmed after tumor resection by immunohistochemistry as well as electron microscopy. The patient underwent abdominal-thoracicen bloc esophagectomy with mediastinal lymphadenectomy and intrathoracic esophagogastrostomy. Results: Our therapeutic concept for the first case of a high-grade MPNST (malignant schwannoma) of the esophagus resulted in a recurrence-free interval of 4 years. Conclusion: The therapy of choice was abdominal-thoracic en bloc esophagectomy with tumor-free resection margins and esophageal reconstruction with the stomach. After R0-resection we found no indication for adjuvant radio- and/or chemotherapy.
Thomas Manger, MD
Department of Surgery, Otto von Guericke University
D–39120 Magdeburg (Germany)
Tel. +49 391 67 15500, Fax +49 391 67 15570
Number of Print Pages : 5
Number of Figures : 7, Number of Tables : 1, Number of References : 16
Digestive Surgery (Official Journal of Collegium Internationale Chirurgiae Digestivae (CICD); Official Journal of European Digestive Surgery (EDS))
Vol. 17, No. 6, Year 2000 (Cover Date: 2000)
Journal Editor: M.W. Büchler, Bern; E.H. Farthmann, Freiburg i.Br.
ISSN: 0253–4886 (print), 1421–9983 (Online)
For additional information: http://www.karger.com/journals/dsu