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Table of Contents
Vol. 17, No. 6, 2000
Issue release date: 2000
Section title: Case Reports
Dig Surg 2000;17:640–643
(DOI:10.1159/000051977)

Hepatic Adenoma Associated with Recombinant Human Growth Hormone Therapy in a Patient with Turner’s Syndrome

Espat J. · Chamberlain R.S. · Sklar C. · Blumgart L.H.
Hepatobiliary Service, Departments of aSurgery and bPediatrics, Memorial Sloan-Kettering Cancer Center, New York, N.Y., USA

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Article / Publication Details

First-Page Preview
Abstract of Case Reports

Published online: 1/16/2001
Issue release date: 2000

Number of Print Pages: 4
Number of Figures: 2
Number of Tables: 0

ISSN: 0253-4886 (Print)
eISSN: 1421-9883 (Online)

For additional information: http://www.karger.com/DSU

Abstract

Background: Turner’s syndrome is a genetic disorder of females with well-described karyotypic abnormalities and phenotypic features. Recombinant human growth hormone (HGH) therapy is one component of a hormonal treatment strategy for these patients and is used to promote sexual maturity and to increase height. Methods: Literature review of hepatic complications following the initiation of growth hormone therapy for patients with Turner’s syndrome, and case report presentation of a 13-year-old female with Turner’s syndrome developing a hepatic adenoma following 3 years of HGH treatment. Results: The association between Turner’s syndrome and HGH treatment-associated hepatic adenoma has not been described previous to this report. In this patient, surgical resection was contraindicated and the patient was successfully treated by hepatic artery embolization. The unique management issues relating to this case, and a possible association between HGH therapy and the development of hepatic adenoma are discussed. Conclusion: This work represents the first documentation of a hepatic adenoma developing in a patient with Turner’s syndrome following HGH treatment, and suggests a novel and causal association between HGH treatment and the development of hepatic adenoma in patients with Turner’s syndrome.


  

Author Contacts

Leslie H. Blumgart, MD, FACS, FRCS
Chief, Division of Hepatobiliary Surgery
Department of Surgery, Memorial Sloan-Kettering Cancer Center
1257 York Avenue, New York, NY 10021 (USA)
Tel. +1 212 639 5526, Fax +1 212 794 5852

  

Article Information

Number of Print Pages : 4
Number of Figures : 2, Number of Tables : 0, Number of References : 10

  

Publication Details

Digestive Surgery (Official Journal of Collegium Internationale Chirurgiae Digestivae (CICD); Official Journal of European Digestive Surgery (EDS))

Vol. 17, No. 6, Year 2000 (Cover Date: 2000)

Journal Editor: M.W. Büchler, Bern; E.H. Farthmann, Freiburg i.Br.
ISSN: 0253–4886 (print), 1421–9983 (Online)

For additional information: http://www.karger.com/journals/dsu


Article / Publication Details

First-Page Preview
Abstract of Case Reports

Published online: 1/16/2001
Issue release date: 2000

Number of Print Pages: 4
Number of Figures: 2
Number of Tables: 0

ISSN: 0253-4886 (Print)
eISSN: 1421-9883 (Online)

For additional information: http://www.karger.com/DSU


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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