Hepatic Adenoma Associated with Recombinant Human Growth Hormone Therapy in a Patient with Turner’s SyndromeEspat J. · Chamberlain R.S. · Sklar C. · Blumgart L.H.
Hepatobiliary Service, Departments of aSurgery and bPediatrics, Memorial Sloan-Kettering Cancer Center, New York, N.Y., USA
Background: Turner’s syndrome is a genetic disorder of females with well-described karyotypic abnormalities and phenotypic features. Recombinant human growth hormone (HGH) therapy is one component of a hormonal treatment strategy for these patients and is used to promote sexual maturity and to increase height. Methods: Literature review of hepatic complications following the initiation of growth hormone therapy for patients with Turner’s syndrome, and case report presentation of a 13-year-old female with Turner’s syndrome developing a hepatic adenoma following 3 years of HGH treatment. Results: The association between Turner’s syndrome and HGH treatment-associated hepatic adenoma has not been described previous to this report. In this patient, surgical resection was contraindicated and the patient was successfully treated by hepatic artery embolization. The unique management issues relating to this case, and a possible association between HGH therapy and the development of hepatic adenoma are discussed. Conclusion: This work represents the first documentation of a hepatic adenoma developing in a patient with Turner’s syndrome following HGH treatment, and suggests a novel and causal association between HGH treatment and the development of hepatic adenoma in patients with Turner’s syndrome.
Leslie H. Blumgart, MD, FACS, FRCS
Chief, Division of Hepatobiliary Surgery
Department of Surgery, Memorial Sloan-Kettering Cancer Center
1257 York Avenue, New York, NY 10021 (USA)
Tel. +1 212 639 5526, Fax +1 212 794 5852
Number of Print Pages : 4
Number of Figures : 2, Number of Tables : 0, Number of References : 10
Digestive Surgery (Official Journal of Collegium Internationale Chirurgiae Digestivae (CICD); Official Journal of European Digestive Surgery (EDS))
Vol. 17, No. 6, Year 2000 (Cover Date: 2000)
Journal Editor: M.W. Büchler, Bern; E.H. Farthmann, Freiburg i.Br.
ISSN: 0253–4886 (print), 1421–9983 (Online)
For additional information: http://www.karger.com/journals/dsu