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Vol. 39, No. 4, 2001
Issue release date: April 2001
Section title: Case Report
Eur Urol 2001;39:484–488
(DOI:10.1159/000052490)

Solitary Fibrous Tumour of the Urinary Bladder with Expression of bcl–2, CD34, and Insulin–Like Growth Factor Type II

Corti B. · Carella R. · Gabusi E. · D’Errico A. · Martorana G. · Grigioni W.F.
aPathology Division of the ‘Felice Addarii’ Institute, Department of Oncology and Haematology, Bologna University School of Medicine, and bDepartment of Nephrology and Urology, Bologna University School of Medicine, Bologna, Italy

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Article / Publication Details

First-Page Preview
Abstract of Case Report

Published online: 4/2/2001

Number of Print Pages: 5
Number of Figures: 4
Number of Tables: 2

ISSN: 0302-2838 (Print)
eISSN: 1421-993X (Online)

For additional information: http://www.karger.com/EUR

Abstract

We describe a solitary fibrous tumour of the urinary bladder wall removed from a 50–year–old man with a history of pelvic pain, dysuria, and urinary bleeding. Anamnesis revealed a weight increase during the preceding 3 months, but no apparent episodes of biochemical hypoglycaemia or hormonal abnormalities. The patient is alive and well 18 months after surgery. Pathological examination revealed a 6.5–cm well–circumscribed nodular mass composed of uniform spindle cells arranged in bundles and fascicles with varying amounts of collagen and a typical haemangiopericytoma–like vascular pattern. The tumour cells were positive for bcl–2, CD34, and vimentin and ultrastructurally showed mesenchymal–myofibroblastic traits. These cells produced insulin–like growth factor type II mRNA as demonstrated by non–isotopic in situ hybridization. This rare case with a solitary fibrous tumor suggests that insulin–like growth factor type II could join CD34 and bcl–2 as markers for postoperative differential diagnosis.


  

Author Contacts

Walter F. Grigioni
Istituto Oncologico ‘Felice Addarii’
Azienda Ospedaliera Policlinico S. Orsola–Malpighi, viale Ercolani 4/2
I–40138 Bologna (Italy)
Tel. +39 51 6364546, Fax +39 51 6364403, E–Mail grigioni@med.unibo.it

  

Article Information

Accepted after revision: April 4, 2000
Number of Print Pages : 5
Number of Figures : 4, Number of Tables : 2, Number of References : 25

  

Publication Details

European Urology
Official Organ of the European Association of Urology

Vol. 39, No. 4, Year 2001 (Cover Date: April 2001)

Journal Editor: C.C. Schulman, Brussels
ISSN: 0302–2838 (print), 1421–993X (Online)

For additional information: http://www.karger.ch/journals/eur


Article / Publication Details

First-Page Preview
Abstract of Case Report

Published online: 4/2/2001

Number of Print Pages: 5
Number of Figures: 4
Number of Tables: 2

ISSN: 0302-2838 (Print)
eISSN: 1421-993X (Online)

For additional information: http://www.karger.com/EUR


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