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Table of Contents
Vol. 9, No. 5, 2001
Issue release date: 2001
Section title: Minireview
Exp Nephrol 2001;9:295–300
(DOI:10.1159/000052624)

Apoptosis and Angiotensin II: Yet Another Renal Regulatory System?

Bonnet F. · Cao Z. · Cooper M.E.
Department of Medicine, University of Melbourne, Austin and Repatriation Medical Centre, Heidelberg West, Vic., Australia

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Article / Publication Details

First-Page Preview
Abstract of Minireview

Published online: August 31, 2001
Issue release date: 2001

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 1

ISSN: (Print)
eISSN: 1660-2129 (Online)

For additional information: http://www.karger.com/NEE

Abstract

Apoptosis plays a key role in the regulation of normal renal structure and kidney remodeling in various renal diseases. Angiotensin II plays a prominent role in renal injury through its receptor subtypes, the type 1 (AT1) receptor and the type 2 (AT2) receptor, which involve different molecular mechanisms. In addition to its haemodynamic actions, angiotensin II induces apoptosis. Angiotensin II also increases proliferation in the kidney. A close correlation between renal cell proliferation and apoptosis has been shown in renal diseases as well as in the angiotensin II infusion model. Angiotensin induces upregulation of p53 and other pro-apoptotic proteins. Recent studies suggest that both AT1 and AT2 receptors influence the apoptotic process in the kidney. These apoptotic effects of angiotensin II should be considered as representing another regulatory mechanism that may modulate the balance between cell growth and proliferation within the kidney.

© 2001 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Minireview

Published online: August 31, 2001
Issue release date: 2001

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 1

ISSN: (Print)
eISSN: 1660-2129 (Online)

For additional information: http://www.karger.com/NEE


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