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Table of Contents
Vol. 50, Suppl. 1, 1998
Issue release date: July 1998
Section title: Vascular and Neural Complications
Horm Res 1998;50(suppl 1):17–22
(DOI:10.1159/000053097)

Diabetic Glomerulopathy in Young IDDM Patients

Preventive and Diagnostic Aspects

Rudberg S.a · Osterby R.b
a Institution of Women and Child Health, Pediatric Unit, Karolinska Institute, Stockholm, Sweden; b Electron Microscopy Laboratory, Institute of Experimental Clinical Research and Institute of Pathology, Aarhus Kommunehospital, Aarhus, Denmark

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Article / Publication Details

First-Page Preview
Abstract of Vascular and Neural Complications

Published online: November 17, 2004
Issue release date: July 1998

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: http://www.karger.com/HRP

Abstract

The clinical course of diabetic nephropathy may be described in stages; the normo-, micro- and macroalbuminuric stage. The basis for its development is the diabetic glomerulopathy in which accumulation of basement membrane (BM) material is pivotal. Normoalbuminuric patients have normal or slightly increased BM thickness; microalbuminuric patients show further BM thickening and mesangial expansion, formation of new capillaries, arteriolar and interstitial changes. The degree of diabetic glomerulopathy may be predicted by long-term glycemic control, diabetes duration and glomerular filtration rate (GFR). A slight decline in GFR in microalbuminuric patients is associated with increases in BM thickness, capillary diameter and interstitial volume fraction. In turn, the degree of early diabetic glomerulopathy may predict the level of microalbuminuria several years later. Improved metabolic control, even to not normal levels, retards the increase of BM thickness and matrix volume in microalbuminuric adolescents. If matrix accumulation may be prevented diabetic nephropathy will not develop. Morphometric analyses may thus be useful in evaluating the effect of intervention, also during shorter periods and at early stages.


Article / Publication Details

First-Page Preview
Abstract of Vascular and Neural Complications

Published online: November 17, 2004
Issue release date: July 1998

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: http://www.karger.com/HRP


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.