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Vol. 50, Suppl. 2, 1998
Issue release date: July 1998
Section title: Paper
Horm Res 1998;50(suppl 2):7–14
(DOI:10.1159/000053118)

Wide Distribution of Laminin-5 γ2 Chain in Basement Membranes of Various Human Tissues

Mizushima H. · Koshikawa N. · Moriyama K. · Takamura H. · Nagashima Y. · Hirahara F. · Miyazaki K.
a Division of Cell Biology, Kihara Institute for Biological Research, Yokohama CityUniversity, and Departments of b Pathology and c Obstetrics and Gynecology, Yokohama City University School of Medicine, Yokohama, Japan

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 11/17/2004

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: http://www.karger.com/HRP

Abstract

Laminin 5 (LN5), a heterotrimer of laminin α3, β3, and γ2 chains, is a laminin isoform which strongly promotes adhesion, migration, and scattering of cells through binding to integrins α3β1, α6β1 and α6β4. To get an insight into the physiological functions of LN5, we prepared a mouse monoclonal antibody to human laminin γ2 chain and used it for immunohistochemical analysis of laminin γ2 chain in normal human tissues. The basement membranes of various epithelial tissues, such as the skin, lung, small intestine, stomach, kidney and prostate, were immunostained with the anti-laminin γ2 chain monoclonal antibody. In addition, the basement membrane of the surface germinal epithelium in the ovary was also positive for laminin γ2 chain. These results suggest general roles of LN5 in the anchorage of various types of epithelial cells to the underlying basement membrane and in the expression of their cellular functions. Moreover, deposition of laminin γ2 chain around small arteries and veins was observed in the thymus and spleen. This lymphatic organ-specific expression of vascular LN5 might provide a novel function of LN5 in immune responses.


  

Author Contacts

Kaoru Miyazaki, PhD
Division of Cell Biology, Kihara Institute for Biological Research
Yokohama City University
642-12 Maioka-cho, Totsuka-ku, Yokohama 244 (Japan)
Tel. +81 45 820 1905, Fax +81 45 820 1901, E-Mail miyazaki@yokohama-cu.ac.jp

  

Article Information

Number of Print Pages : 8
Number of Figures : 4, Number of Tables : 1, Number of References : 38

  

Publication Details

Hormone Research (International Journal of Experimental and Clinical Endocrinology)
Founded 1970 as ‘Hormones’ by M. Marois, Continued 1976 by J. Girard (1976–1995)
Official Organ of the European Society for Paediatric Endocrinology

Vol. 50, No. Suppl. 2, Year 1998 (Cover Date: Released July 1998)

Journal Editor: M.B. Ranke, Tübingen
ISSN: 0301–0163 (print), 1423–0046 (Online)

For additional information: http://www.karger.com/journals/hre


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 11/17/2004

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: http://www.karger.com/HRP


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