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Original Paper

Metabolic Studies of a Synthetic Lipolytic Domain (AOD9604) of Human Growth Hormone

Ng F.M. · Sun J. · Sharma L. · Libinaka R. · Jiang W.J. · Gianello R.

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Department of Biochemistry and Molecular Biology, Monash University, Clayton, Vic., Australia

Related Articles for ""

Horm Res 2000;53:274–278

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: January 10, 2001
Issue release date: 2000

Number of Print Pages: 5
Number of Figures: 4
Number of Tables: 0

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: http://www.karger.com/HRP

Abstract

A synthetic analogue (AOD9604) of the lipolytic domain of human growth hormone (hGH) has been studied for its metabolic actions in obese Zucker rats. Daily treatment with an oral dose of AOD9604 of 500 µg/kg body weight for 19 days reduced over 50% (15.8 ± 0.6 vs. 35.6 ± 0.8 g) body weight gain of the animals in comparison with the control. The adipose tissues of the AOD9604–treated animals were found to have an increase in lipolytic activity. In contrast to chronic treatment with intact hGH, chronic treatment with AOD9604 showed no adverse effect on insulin sensitivity of the animals, as demonstrated with euglycemic clamp techniques. The results in the present study suggest that the analogue of the hGH lipolytic domain may have the potential to be developed into an orally usable and safe therapeutic agent for obesity.

© 2001 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: January 10, 2001
Issue release date: 2000

Number of Print Pages: 5
Number of Figures: 4
Number of Tables: 0

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: http://www.karger.com/HRP


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