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Table of Contents
Vol. 54, No. 2, 2000
Issue release date: 2000
Section title: Original Paper
Horm Res 2000;54:92–97
(DOI:10.1159/000053238)

Evaluation of Cutaneous Modifications in Seventy-Seven Growth Hormone-Deficient Children

Conte F. · Diridollou S. · Jouret B. · Turlier V. · Charveron M. · Gall Y. · Rochiccioli P. · Bieth E. · Tauber M.
aCentre de Recherche sur la Croissance, Pavillon Leriche, Centre Hospitalier Universitaire de Purpan, Toulouse, and Pharmacia France, Guyancourt, France, and Pharmacia Sweden, Stockholm, Sweden; bEquipe d’Endocrinologie, Génétique et Gynécologie Médicale, Hôpital des Enfants, Toulouse, et cInstitut de Recherche Pierre-Fabre, Centre Jean-Louis-Alibert, Toulouse, France

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 3/9/2001

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 2

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: http://www.karger.com/HRP

Abstract

Cutaneous parameters such as dermal thickness, stiffness, elasticity, skin surface lipid and hydration were evaluated using noninvasive methods in 77 growth hormone-deficient (GHD) children before replacement therapy and in 70 non-GHD children. We showed that in GHD children, dermis was thinner (0.70 ± 0.10 vs. 0.80 ± 0.10 mm, p < 0.0001 for prepubertal children and 0.81 ± 0.10 vs. 0.94 ± 0.11 mm, p < 0.0001 for pubertal children), stiffer (178.5 ± 57.3 vs. 113.09 ± 37 kPa, p < 0.0001 for prepubertal children and 172.5 ± 61.7 vs. 117.3 ± 42.5 kPa for pubertal children, p < 0.001) and less elastic (0.44 ± 0.09 vs. 0.39 ± 0.06 (nonelasticity index), p < 0.01 for prepubertal children and 0.39 ± 0.05 vs. 0.33 ± 0.04, p < 0.001 for pubertal children) compared to controls. Fourteen GHD children were re-evaluated after 1 year of GH treatment: dermal thickness and skin stiffness were significantly improved (p < 0.001 and p < 0.05 respectively) while elasticity was not modified. During the same period, 11 controls did not show any significant cutaneous modification. IGF-1 values, but not IGFBP-3 values, correlated positively with dermal thickness in GHD children, before and after 1 year of GH treatment. To conclude, GHD children exhibited specific cutaneous modifications. In a subset of GHD children, we showed that these modifications were influenced by GH treatment. More extensive studies are needed to see if these changes correlated with other GH effects.


  

Author Contacts

Dr. Françoise Conte
Centre de Recherche sur la Croissance, Pavillon Leriche
Centre Hospitalier Universitaire de Purpan, Place du Dr. Baylac
F–31509 Toulouse (France)
Tel. +33 5 61 77 75 69, Fax +33 5 61 77 99 93

  

Article Information

Received: Received: June 2, 2000
Accepted: October 31, 2000
Number of Print Pages : 6
Number of Figures : 2, Number of Tables : 2, Number of References : 27

  

Publication Details

Hormone Research (International Journal of Experimental and Clinical Endocrinology)
Founded 1970 as ‘Hormones’ by M. Marois, Continued 1976 by J. Girard (1976–1995)
Official Organ of the European Society for Paediatric Endocrinology

Vol. 54, No. 2, Year 2000 (Cover Date: 2000)

Journal Editor: M.B. Ranke, Tübingen
ISSN: 0301–0163 (print), 1423–0046 (Online)

For additional information: http://www.karger.com/journals/hre


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 3/9/2001

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 2

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: http://www.karger.com/HRP


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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