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Vol. 124, No. 4, 2001
Issue release date: April 2001
Section title: Review
Int Arch Allergy Immunol 2001;124:423–431
(DOI:10.1159/000053777)

Chemokines, Chemokine Receptors and Allergy

Kaplan A.P.
Division of Pulmonary Diseases and Central Case Medicine and Allergy and Clinical Immunology, Department of Medicine, Medical University of South Carolina, Charleston, S.C., USA

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Article / Publication Details

First-Page Preview
Abstract of Review

Published online: 4/27/2001

Number of Print Pages: 9
Number of Figures: 2
Number of Tables: 5

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA

Abstract

Chemokines are a group of cytokines that are responsible for the influx of blood cells, including T and B lymphocytes, monocytes, neutrophils, eosinophils and basophils, in allergic and other inflammatory conditions. They function as G protein-coupled chemotactic factors which also activate the cells with which they interact. Certain chemokines function within the afferent arm of the immune system, in which antigen is processed and antibody formation initiated, and others are active within the effector pathways of cellular immunity and late-phase allergic reactions. Th2 lymphocytes, which are critical for allergy, employ the CC chemokine receptors CCR4 and CCR8 with the ligands thymus- and activation-regulated chemokine (TARC), macrophage-derived chemokine (MDC) and I-309, respectively. The chemokine receptor CCR3 and ligands monocyte chemoattractant protein (MCP)-3, MCP-4, regulated upon activation normal T cell expressed and secreted (RANTES) and eotaxins I and II are of particular relevance for the recruitment and activation of eosinophils. Th1 reactions depend upon interferon γ-induced CXC chemokines interferon- inducible protein (IP)-10, interferon-inducible T cell-α chemoattractant (iTAC) and monokine induced by interferon-γ (MiG), which bind to chemokine receptor CXCR3.


  

Author Contacts

Correspondence to: Prof. Allen P. Kaplan
Medical University of South Carolina, Department of Medicine
Division of Pulmonary, Allergy and Critical Care
171 Ashley Avenue, Charleston, SC 29425-2220 (USA)
Tel. +1 843 792 2468, Fax +1 843 792 0732, E-Mail kaplana@musc.edu

  

Article Information

Number of Print Pages : 9
Number of Figures : 2, Number of Tables : 5, Number of References : 57

  

Publication Details

International Archives of Allergy and Immunology
Founded 1950

Vol. 124, No. 4, Year 2001 (Cover Date: April 2001)

Journal Editor: D. Kraft, Vienna
ISSN: 1018–2438 (print), 1423–0097 (Online)

For additional information:http://www.karger.com/journals/iaa


Article / Publication Details

First-Page Preview
Abstract of Review

Published online: 4/27/2001

Number of Print Pages: 9
Number of Figures: 2
Number of Tables: 5

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA


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