γδ T Cells as Regulators of Airway HyperresponsivenessLahn M.a · Kanehiro A.b · Takeda K.b · Konowal A.a · O’Brien R.L.a · Gelfand E.W.b · Born W.K.a
Departments of aImmunology and bPediatrics at National Jewish Medical and Research Center, Denver, Colo., USA
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Airway responsiveness (AR) is determined by complex mechanisms reflecting lung responses to airborne stimuli. Murine studies have identified a number of potential factors modulating AR and thus have contributed to the current understanding of these mechanisms. In allergic inflammation, immune cells, in particular αβ T cells, have emerged as important contributors to increased AR. We have found that in contrast to αβ T cells, γδ T cells can have a negative regulatory effect on AR. Here, we review the current studies on γδ T cells in allergic inflammation and discuss their role in modulating AR. We propose that γδ T cells exhibit different immune properties depending on the type of stimulus and inflammation. These differential immune properties appear to be associated with specific γδ T cell subsets, which control AR to airborne stimuli. In particular, our recent data indicate that the Vγ4+ T cell subset acts as an important negative regulator of AR and contributes to maintaining normal lung function in mice.
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