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Table of Contents
Vol. 16, No. 2, 2001
Issue release date: March–April 2001
Section title: Paper
Fetal Diagn Ther 2001;16:105–110
(DOI:10.1159/000053891)

Outcome of Fetal Cystic Hygroma and Experience of Intrauterine Treatment

Ogita K. · Suita S. · Taguchi T. · Yamanouchi T. · Masumoto K. · Tsukimori K. · Nakano H.
Departments of aPediatric Surgery and bObstetrics and Gynecology, Faculty of Medicine, Kyushu University, and cMaternity and Perinatal Care Unit, Kyushu University Hospital, Fukuoka, Japan

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 2/16/2001

Number of Print Pages: 6
Number of Figures: 5
Number of Tables: 0

ISSN: 1015-3837 (Print)
eISSN: 1421-9964 (Online)

For additional information: http://www.karger.com/FDT

Abstract

Objective: To review our cases of fetal cystic hygroma and to examine the prognostic factors with the goal of establishing criteria for the intrauterine treatment for cystic hygroma. Patients and Methods: Thirty-one cases of fetal cystic hygroma were managed by us from January 1988 to December 1997, and 21 cases were available for analysis. Three prognostic factors, namely chromosomal abnormality, structural anomaly and hydrops fetalis, were evaluated. We treated 2 cases of cystic hygroma associated with hydrops fetalis in utero using OK-432 injection under ultrasound guidance. Results: The fetuses without any of the prognostic factors listed above showed a good prognosis throughout the fetal and neonatal periods. However, in this group, 2 infants with large tumors died of hemorrhage from the tumor at 6 months and 3 years of age, respectively. Cases with hydrops fetalis without chromosomal abnormalities or structural anomalies (5 cases) resulted in either intrauterine fetal death (IUFD, 2 cases) or early perinatal neonatal death (early PND, 3 cases). The cause of early PND was circulatory failure. Most of the hydrops cases with either a chromosomal abnormality or structural anomaly resulted in IUFD before 22 weeks of gestation. The size of the cyst decreased in 1 of 2 cases treated in utero. Conclusions: The fetal cases of cystic hygroma showing hydrops fetalis without chromosomal abnormalities or structural anomalies are considered to be possible candidates for intrauterine therapy. Those with very large cystic hygroma without any of the three prognostic factors are also thought to be candidates for fetal treatment. Based on our clinical experience, sclerotherapy using OK-432 is considered to be a treatment option in selected cases with fetal cystic hygroma.


  

Author Contacts

Keiko Ogita, MD
Department of Pediatric Surgery
Faculty of Medicine, Kyushu University
3-1-1, Maidashi, Higashi-ku, Fukuoka 812-8582 (Japan)
Tel. +81 92 642 5573, Fax +81 92 642 5580, E-Mail Keiko813@aol.com

  

Article Information

Received: Received: December 28, 1999
Accepted after revision: July 27, 2000
Number of Print Pages : 6
Number of Figures : 5, Number of Tables : 0, Number of References : 10

  

Publication Details

Fetal Diagnosis and Therapy (Clinical Advances and Basic Research)
Formerly ‘Fetal Therapy’
Official Organ of the ‘International Fetal Medicine, Surgery Society’ and the International Society ‘Fetus as a Patient’

Vol. 16, No. 2, Year 2001 (Cover Date: March-April 2001)

Journal Editor: W. Holzgreve, Basel
ISSN: 1015–3837 (print), 1421–9964 (Online)

For additional information: http://www.karger.com/journals/fdt


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 2/16/2001

Number of Print Pages: 6
Number of Figures: 5
Number of Tables: 0

ISSN: 1015-3837 (Print)
eISSN: 1421-9964 (Online)

For additional information: http://www.karger.com/FDT


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