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Vol. 42, No. 5-6, 1999
Issue release date: September–December 1999 (February 2000)
Section title: Part I. Immunopathology. Immune Escape and Reactivation
Intervirology 1999;42:308–313
(DOI:10.1159/000053965)

Human Cytomegalovirus Reactivation in Bone-Marrow-Derived Granulocyte/Monocyte Progenitor Cells and Mature Monocytes

Prösch S. · Döcke W-D. · Reinke P. · Volk H-D. · Krüger D.H.
Departments of aVirology, bMedical Immunology and cNephrology/Internal Intensive Care Medicine, School of Medicine (Charité), Humboldt University, Berlin, Germany

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Article / Publication Details

First-Page Preview
Abstract of Part I. Immunopathology. Immune Escape and Reactivation

Published online: 2/28/2000

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 0

ISSN: 0300-5526 (Print)
eISSN: 1423-0100 (Online)

For additional information: http://www.karger.com/INT

Abstract

Monocyte/granulocyte progenitor cells of the bone marrow are a major site of human cytomegalovirus (HCMV) latency. The mechanisms of establishment and maintenance of HCMV latency are still unknown. Reactivation of the latent virus in bone-marrow-derived progenitor cells has been demonstrated in vitro and suggested to occur also in vivo. Clinical studies have shown that reactivation is a rather frequent event not only in immunosuppressed but also in nonimmunosuppressed patients and in healthy blood donors. At least three independent mechanisms of virus reactivation are discussed: systemic inflammation connected with strong tumor necrosis factor alpha release; application of cAMP-elevating drugs, and highly stressful events associated with increased plasma catecholamine levels.


  

Author Contacts

PD Dr. Susanna Prösch
Institut für Virologie, Universitätsklinikum Charité
Campus Charité-Mitte, Humboldt-Universität
Schumannstrasse 20/21, D–10098 Berlin (Germany)
Tel. +49 30 2802 3117, Fax +49 30 2802 2180, E-Mail susanna.proesch@charite.de

  

Article Information

Number of Print Pages : 6
Number of Figures : 1, Number of Tables : 0, Number of References : 53

  

Publication Details

Intervirology (International Journal of Basic and Medical Virology)
Founded 1973 by J.L. Melnick; continued by F. Rapp (1986–1990); M.J. Buchmeier and C.R. Howard (1991–1993)

Vol. 42, No. 5-6, Year 1999 (Cover Date: September-December 1999 (Released February 2000))

Journal Editor: Rüdiger W. Braun, Stuttgart
ISSN: 0300–5526 (print), 1423–0100 (Online)

For additional information: http://www.karger.com/journals/int


Article / Publication Details

First-Page Preview
Abstract of Part I. Immunopathology. Immune Escape and Reactivation

Published online: 2/28/2000

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 0

ISSN: 0300-5526 (Print)
eISSN: 1423-0100 (Online)

For additional information: http://www.karger.com/INT


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