Human Cytomegalovirus Reactivation in Bone-Marrow-Derived Granulocyte/Monocyte Progenitor Cells and Mature MonocytesPrösch S. · Döcke W-D. · Reinke P. · Volk H-D. · Krüger D.H.
Departments of aVirology, bMedical Immunology and cNephrology/Internal Intensive Care Medicine, School of Medicine (Charité), Humboldt University, Berlin, Germany
Monocyte/granulocyte progenitor cells of the bone marrow are a major site of human cytomegalovirus (HCMV) latency. The mechanisms of establishment and maintenance of HCMV latency are still unknown. Reactivation of the latent virus in bone-marrow-derived progenitor cells has been demonstrated in vitro and suggested to occur also in vivo. Clinical studies have shown that reactivation is a rather frequent event not only in immunosuppressed but also in nonimmunosuppressed patients and in healthy blood donors. At least three independent mechanisms of virus reactivation are discussed: systemic inflammation connected with strong tumor necrosis factor alpha release; application of cAMP-elevating drugs, and highly stressful events associated with increased plasma catecholamine levels.
PD Dr. Susanna Prösch
Institut für Virologie, Universitätsklinikum Charité
Campus Charité-Mitte, Humboldt-Universität
Schumannstrasse 20/21, D–10098 Berlin (Germany)
Tel. +49 30 2802 3117, Fax +49 30 2802 2180, E-Mail firstname.lastname@example.org
Number of Print Pages : 6
Number of Figures : 1, Number of Tables : 0, Number of References : 53
Intervirology (International Journal of Basic and Medical Virology)
Founded 1973 by J.L. Melnick; continued by F. Rapp (1986–1990); M.J. Buchmeier and C.R. Howard (1991–1993)
Vol. 42, No. 5-6, Year 1999 (Cover Date: September-December 1999 (Released February 2000))
Journal Editor: Rüdiger W. Braun, Stuttgart
ISSN: 0300–5526 (print), 1423–0100 (Online)
For additional information: http://www.karger.com/journals/int