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Table of Contents
Vol. 37, No. 6, 2000
Issue release date: November – December
Section title: Research Paper
J Vasc Res 2000;37:513–522
(DOI:10.1159/000054084)

Scanning Laser-Doppler Flowmetry of Rat Cerebral Circulation during Cortical Spreading Depression

Nielsen A.N.a · Fabricius M.b · Lauritzen M.a,b
aDepartment of Medical Physiology, University of Copenhagen, and bDepartment of Clinical Neurophysiology, Glostrup Hospital, Copenhagen, Denmark

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Article / Publication Details

First-Page Preview
Abstract of Research Paper

Published online: January 10, 2001
Issue release date: November – December

Number of Print Pages: 10
Number of Figures: 5
Number of Tables: 1

ISSN: 1018-1172 (Print)
eISSN: 1423-0135 (Online)

For additional information: http://www.karger.com/JVR

Abstract

Scanning laser-Doppler flowmetry (SLDF) generates two-dimensional images of blood flow. This study compared SLDF to conventional laser-Doppler flowmetry (LDF) in the cerebral circulation. Test stimuli were episodes of cortical spreading depression (CSD) elicited in brains of halothane anaesthetised rats (n = 9). The LDF instrument used two wavelengths of laser light to record relative changes of cerebral blood flow (CBF) up to an approximate depth of 250 µm (543 nm) and 500 µm (780 nm). Under resting conditions, SLDF images showed a heterogeneous pattern of flow in pial vessels with high flow rates in arterioles, and lower rates in venules and small vessels (<30 µm). Arterioles constituted about 6%, venules 12% and small vessels 2% of the image area, while approximately 80% were background with a laser-Doppler signal corresponding to zero calibration. During CSD, the relative increase of area was largest for small vessels and less for venules and arterioles. Similar changes were observed for blood flow in the three vessel structures. For both wavelengths of LDF, flow changes correlated with SLDF (r ≈ 0.7). In conclusion, SLDF provides images of flow in pial vessels and capillaries at, or just beneath the cortical surface. SLDF and LDF are complementary, but cannot substitute for one another as they measure flow in different layers of the cortex.

© 2000 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Research Paper

Published online: January 10, 2001
Issue release date: November – December

Number of Print Pages: 10
Number of Figures: 5
Number of Tables: 1

ISSN: 1018-1172 (Print)
eISSN: 1423-0135 (Online)

For additional information: http://www.karger.com/JVR


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