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Vol. 73, No. 5, 2001
Issue release date: May 2001
Section title: Stress, Corticotropin and Behaviour
Neuroendocrinology 2001;73:312–321
(DOI:10.1159/000054648)

Hypothalamo-Pituitary-Adrenal Axis Activity Is Related to the Level of Central Arousal: Effect of Sleep Deprivation on the Association of High-Frequency Waking Electroencephalogram with Cortisol Release

Chapotot F. · Buguet A. · Gronfier C. · Brandenberger G.
aLaboratoire des Régulations Physiologiques et des Rythmes Biologiques chez l’Homme, Institut de Physiologie, Faculté de Médecine, ULP, Strasbourg, et bUnité de Physiologie de la Vigilance, Département des Facteurs Humains, Centre de Recherches du Service de Santé des Armées ‘Emile Pardé’, La Tronche, France

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Article / Publication Details

First-Page Preview
Abstract of Stress, Corticotropin and Behaviour

Published online: 5/31/2001

Number of Print Pages: 10
Number of Figures: 4
Number of Tables: 2

ISSN: 0028-3835 (Print)
eISSN: 1423-0194 (Online)

For additional information: http://www.karger.com/NEN

Abstract

The temporal and quantitative interrelationships between the hypothalamo-pituitary-adrenal (HPA) axis activity and the level of central arousal were studied in 10 healthy young men during daytime wakefulness. Two experimental sessions were conducted randomly between 09.00 and 18.00 h, once after nocturnal sleep and once after a night of total sleep deprivation. Spectral analysis of serial waking electroencephalography (EEG) from a short target fixation task repeated every 10 min was undertaken, along with an estimation of cortisol secretory profiles by deconvolution of plasma radioimmunoassay measures obtained from continuous blood withdrawal with regular sampling at a 10-min interval. Following nocturnal sleep, a temporal association between the HPA axis activity and the waking EEG activity was found, cortisol secretory rate following changes in frontal gamma (20–45 Hz) band power by 10 min (average R = 0.458, p < 0.001). Although it remained significant (average R = 0.276, p < 0.05), the association strength decreased significantly following total sleep deprivation (p < 0.05, Wilcoxon test). Cortisol plasma level, secretory rate and pulse amplitude were increased as well as waking EEG power in the delta (0.5–5.5 Hz), theta (5.5–8.5 Hz) and gamma frequency bands (all p values <0.05, Student t tests). The sleep deprivation-related increases in cortisol secretory rate and waking EEG gamma activity were quantitatively associated (R = 0.504, p < 0.05). These results support the existence of a common ultradian regulatory mechanism, co-ordinating HPA axis activity to the level of central arousal in man, which seems involved in the sleep deprivation-induced hyperarousal.


  

Author Contacts

Florian Chapotot
Unité de Physiologie de la Vigilance
24, avenue du Maquis du Grésivaudan, CRSSA ‘Emile Pardé’, BP 87
F–38702 La Tronche Cedex (France)
Tel. +33 4 76 63 97 15, Fax +33 4 76 63 69 45, E-Mail f.chapotot@softhome.net

  

Article Information

Received: Received: June 29, 2000
Accepted after revision: January 15, 2001
Number of Print Pages : 10
Number of Figures : 4, Number of Tables : 2, Number of References : 39

  

Publication Details

Neuroendocrinology (International Journal for Basic and Clinical Studies on Neuroendocrine Relationships)
Founded 1965 by E. Bajusz. Continued by K.M. Knigge (1973–1978), W.F. Ganong (1979–1984), S.M. McCann (1985–1993)
Official Journal of the International Society of Neuroendocrinology

Vol. 73, No. 5, Year 2001 (Cover Date: May 2001)

Journal Editor: C. Kordon, Paris
ISSN: 0028–3835 (print), 1423–0194 (Online)

For additional information: http://www.karger.com/journals/nen


Article / Publication Details

First-Page Preview
Abstract of Stress, Corticotropin and Behaviour

Published online: 5/31/2001

Number of Print Pages: 10
Number of Figures: 4
Number of Tables: 2

ISSN: 0028-3835 (Print)
eISSN: 1423-0194 (Online)

For additional information: http://www.karger.com/NEN


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