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Table of Contents
Vol. 43, No. 2, 2001
Issue release date: February 2001
Section title: Biological Psychiatry. Main Editor: J. Mendlewicz (Brussels) / Original Paper
Neuropsychobiology 2001;43:59–62
(DOI:10.1159/000054867)

Plasma Concentrations of Interleukin-1β, Interleukin-6, Soluble Interleukin-2 Receptor and Tumor Necrosis Factor α of Depressed Patients in Japan

Kagaya A.a · Kugaya A.b · Takebayashi M.a · Fukue-Saeki M.a · Saeki T.a · Yamawaki S.a · Uchitomi Y.b
aDepartment of Psychiatry and Neurosciences, Hiroshima University School of Medicine, Hiroshima, and bPsycho-Oncology Division, National Cancer Center Research Institute East, Kashiwa, Japan

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Article / Publication Details

First-Page Preview
Abstract of Biological Psychiatry. Main Editor: J. Mendlewicz (Brussels)  /  Original Paper

Published online: February 07, 2001
Issue release date: February 2001

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 3

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: http://www.karger.com/NPS

Abstract

There are a number of investigations which indicate the important relationship between depression and cytokines. In this study, we investigated plasma interleukin (IL)-1β, IL-6, soluble IL-2 receptor (sIL-2R) and tumor necrosis factor (TNF)-α of depressed patients whose clinical evaluation was performed by the Hamilton Rating Scale for Depression (HAM-D) and the Profile of Mood States (POMS). They were compared with those of the control subjects, and before and after treatment with antidepressants. Before the treatment, plasma IL-1β, IL-6, sIL-2R and TNF-α of the patients were not significantly different from those of the control subjects. sIL-2R was positively correlated with the POMS-tension-anxiety subscale and tended to have a positive correlation with HAM-D. After pharmacotherapy, TNF-α levels of the depressed patients increased, without any relationship between the change in the HAM-D or the POMS and the change in TNF-α. These results suggest that the plasma sIL-2R concentration is associated with mood state, and that the plasma TNF-α concentration is increased after pharmacotherapy in Japanese depressed patients.

© 2001 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Biological Psychiatry. Main Editor: J. Mendlewicz (Brussels)  /  Original Paper

Published online: February 07, 2001
Issue release date: February 2001

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 3

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: http://www.karger.com/NPS


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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