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Table of Contents
Vol. 43, No. 3, 2001
Issue release date: March 2001
Section title: Biological Psychiatry. Main Editor: J. Mendlewicz (Brussels) / Original Paper
Neuropsychobiology 2001;43:123–126
(DOI:10.1159/000054878)

mRNA Expression of Serotonin Receptors of Type 2C and 5A in Human Resting Lymphocytes

Marazziti D.a · Ori M.b · Nardini M.b · Rossi A.a · Nardi I.b · Cassano G.B.a
aDipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie e bLaboratori di Biologia Cellulare e dello Sviluppo, Dipartimento di Fisiologia e Biochimica, University of Pisa, Italy

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Article / Publication Details

First-Page Preview
Abstract of Biological Psychiatry. Main Editor: J. Mendlewicz (Brussels)  /  Original Paper

Published online: March 30, 2001
Issue release date: March 2001

Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 0

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: http://www.karger.com/NPS

Abstract

We investigated the presence of mRNA for serotonin receptors of type 2C (5-HT2C) in resting lymphocytes by means of RT-PCR and Southern blotting analyses, given their possible role in the pathophysiology of anxiety and eating disorders. At the same time, we explored also the presence of the specific mRNA for 5-HT5A receptors, a novel subtype for which still no functional data exist. Healthy subjects and patients with obsessive-compulsive or bipolar disorders were included in the study. The results showed the presence of the specific mRNAs for both 5-HT2C and 5-HT5A receptors in resting lymphocytes of the three groups of subjects. An additional band was also observed after the amplification of the 5-HT5A cDNA in each sample. These findings, while revealing the presence of 5-HT2C and 5-HT5A receptor mRNAs in an easily available tissue, can be considered preliminary for future quantitative analyses in patients with different psychiatric conditions.

© 2001 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Biological Psychiatry. Main Editor: J. Mendlewicz (Brussels)  /  Original Paper

Published online: March 30, 2001
Issue release date: March 2001

Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 0

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: http://www.karger.com/NPS


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