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Vol. 43, No. 4, 2001
Issue release date: May 2001
Section title: Biological Psychology/Pharmacopsychology. Main Editor: P. Netter (Giessen) / Original Paper
Neuropsychobiology 2001;43:248–253
(DOI:10.1159/000054898)

Polymorphisms in the Dopamine, Serotonin, and Norepinephrine Transporter Genes and Their Relationship to Temperamental Dimensions Measured by the Temperament and Character Inventory in Healthy Volunteers

Samochowiec J. · Rybakowski F. · Czerski P. · Zakrzewska M. · Stepień G. · Pełka-Wysiecka J. · Horodnicki J. · Rybakowski J.K. · Hauser J.
aDepartment of Psychiatry, Pomeranian Academy of Medicine, Szczecin, bDepartment of Child and Adolescent Psychiatry and cLaboratory of Psychiatric Genetics, University of Medical Sciences, dDepartment of Basic Psychological Research, University of Adam Mickiewicz, eDepartment of Adult Psychiatry, University of Medical Sciences, Poznań, Poland

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Article / Publication Details

First-Page Preview
Abstract of Biological Psychology/Pharmacopsychology. Main Editor: P. Netter (Giessen)  /  Original Paper

Published online: 5/2/2001

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 2

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: http://www.karger.com/NPS

Abstract

There is evidence for an association between polymorphisms of monoamine transporter genes and temperamental personality traits. Recent findings have shown that interaction of allelic variants of the different genes may contribute to the personality factors. We studied the association between temperamental personality dimensions measured with the Temperament and Character Inventory (TCI) and polymorphisms of the dopamine (DAT), norepinephrine (NET) and serotonin (5-HTT) transporter genes in 127 healthy Polish volunteers. There were no significant differences between means of TCI temperamental dimensions (novelty seeking, reward dependence, persistence and harm avoidance) and the transporter genes compared by ANOVA. There were some significant associations between genotypes and TCI subdimensions. Individuals carrying the A9/A9 DAT genotype have lower RD4 scores (dependence vs. independence) than A10/A10 individuals (3.0 ± 1.4 vs. 3.5 ± 1.3); p = 0.01. Examining 5-HTT gene promoter polymorphism, heterozygous individuals (l/s) and individuals with 44-bp deletion (s/s) scored significantly lower in the HA1 subdimension (anticipatory worry and pessimism vs. uninhibited optimism; 4.3 ± 2.3 vs. 5.5 ± 2.6) in comparison with individuals without deletion (l/l); p = 0.021. The NET transporter gene polymorphism showed no significant association with any of the temperamental TCI subdimensions.


  

Author Contacts

Jerzy Samochowiec, MD
Department of Psychiatry
Pomeranian Academy of Medicine, Broniewskiego 26
PL–71460 Szczecin (Poland)
Tel. +48 91 4540 653, Fax +48 91 486 29 75, E-Mail samoj@r1.pam.szczecin.pl

  

Article Information

Number of Print Pages : 6
Number of Figures : 0, Number of Tables : 2, Number of References : 32

  

Publication Details

Neuropsychobiology (International Journal of Experimental and Clinical Research in Biological Psychiatry, Pharmacopsychiatry, Biological Psychology/Pharmacopsychology and Pharmacoelectroencephalography)
Founded 1975 by J. Mendlewicz (Brussels)
Official Journal of the International Pharmaco-EEG Society (IPEG)

Vol. 43, No. 4, Year 2001 (Cover Date: Released May 2001)

Journal Editor: J. Mendlewicz, Brussels; B. Saletu, Vienna; P. Netter, Giessen; W.M. Herrmann, Berlin
ISSN: 0302–282X (print), 1423–0224 (Online)

For additional information: http://www.karger.com/journals/nps


Article / Publication Details

First-Page Preview
Abstract of Biological Psychology/Pharmacopsychology. Main Editor: P. Netter (Giessen)  /  Original Paper

Published online: 5/2/2001

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 2

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: http://www.karger.com/NPS


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