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Table of Contents
Vol. 60, No. 1, 2001
Issue release date: December 2000
Section title: Clinical Study
Oncology 2001;60:31–34
(DOI:10.1159/000055293)

Postirradiation Angiosarcoma of the Chest Wall and Breast: Issues of Radiogenic Origin, Diagnosis and Treatment in Two Cases

Polgár C. · Orosz Z. · Szerdahelyi A. · Fodor J. · Major T. · Mágori A. · Czeyda-Pommersheim F. · Vámosi Nagy I. · Szakolczai I. · Fejös Z. · Németh G.
Departments of aRadiotherapy, bPathology, cGeneral and Thoracic Surgery, dChemotherapy B and eDermatology, National Institute of Oncology, Budapest, Hungary

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Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Published online: 12/28/2000

Number of Print Pages: 4
Number of Figures: 3
Number of Tables: 1

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL

Abstract

The authors report two cases of postradiation angiosarcoma (AS) among 5,100 breast cancer patients treated in the period 1980–1994 at the National Institute of Oncology, Budapest. Relevant data in the literature is also reviewed to analyze the questions of radiogenic origin, diagnosis and treatment. Secondary AS occurred in these cases in a previously irradiated field after a 6- and 8-year latency period, respectively. Detailed histopathological and immunohistochemical examinations from the biopsy specimens confirmed the diagnosis as AS. The first patient was treated successfully with radical surgery. The second patient, with unresectable AS, died of rapid local progression within 4 months. The incidence of chest wall and breast AS after radiotherapy was found to be 0.46 per 1,000 in our patient population, which means an estimated odds ratio of 2.9 for secondary AS. Patients treated with radiotherapy for primary breast cancer are at higher risk for developing secondary AS compared to the healthy population. An etiological relationship between radiotherapy and subsequent AS of the chest wall and breast is likely, but still controversial. Initial radical surgery is the only effective treatment for achieving long-term survival. These very rare cases deserve special attention due to the atypical clinical appearance, difficulties of differential diagnosis and poor prognosis.


  

Author Contacts

Csaba Polgár, MD
Department of Radiotherapy, National Institute of Oncology
7–9 Ráth György u.
H–1122 Budapest (Hungary)
Tel. +36 1 224 8600, Fax +36 1 224 8620, E-Mail polgar@oncol.hu

  

Article Information

Number of Print Pages : 4
Number of Figures : 3, Number of Tables : 1, Number of References : 13

  

Publication Details

Oncology (International Journal of Cancer Research and Treatment)
Founded 1948 as ‘Oncologia’ by H.R. Schinz; Continued by V. Richards (1967–1975), H. Wrba (1976–1992)

Vol. 60, No. 1, Year 2001 (Cover Date: Released December 2000)

Journal Editor: P.P. Carbone, Madison, Wisc.
ISSN: 0030–2414 (print), 1423–0232 (Online)

For additional information: http://www.karger.com/journals/onc


Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Published online: 12/28/2000

Number of Print Pages: 4
Number of Figures: 3
Number of Tables: 1

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL


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