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Table of Contents
Vol. 63, No. 1, 2001
Issue release date: January–February 2001
Section title: Original Paper
ORL 2001;63:25–30
(DOI:10.1159/000055702)

Different Clinical Characteristics of Aminoglycoside-Induced Profound Deafness with and without the 1555 A→G Mitochondrial Mutation

Tono T. · Kiyomizu K. · Matsuda K. · Komune S. · Usami S. · Abe S. · Shinkawa H.
aDepartment of Otorhinolaryngology, Miyazaki Medical College, Miyazaki, bDepartment of Otorhinolaryngology, Shinshu University School of Medicine, Matsumoto, and cDepartment of Otorhinolaryngology, Hirosaki University School of Medicine, Hirosaki, Japan

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 1/26/2001
Issue release date: January–February 2001

Number of Print Pages: 6
Number of Figures: 3
Number of Tables: 2

ISSN: 0301-1569 (Print)
eISSN: 1423-0275 (Online)

For additional information: http://www.karger.com/ORL

Abstract

Recent genetic studies have shown that hereditary susceptibility to aminoglycoside antibiotics is caused by the 1555 A→G mitochondrial mutation. We found the 1555 mutation in 4 out of 68 postlingual deaf patients who were candidates for cochlear implantation. All 4 patients developed bilateral profound hearing loss following administration of aminoglycosides. The pedigree of the family shows exclusively maternal transmission of hearing impairment in each case. On comparison with neuro-otological findings from aminoglycoside-induced deaf patients without the 1555 mutation, four distinct characteristics were noted: (1) a progressive nature of hearing loss; (2) better residual pure-tone thresholds; (3) lower thresholds for electrical promontory stimulation, and (4) well-preserved vestibular function. Although other factors such as differing dosages and/or administration routes may also be involved, profound hearing loss associated with the 1555 mutation may be due to a different pathogenic mechanism, i.e., strial dysfunction rather than a direct insult to the hair cells.


  

Author Contacts

Tetsuya Tono
Department of Otorhinolaryngology, Miyazaki Medical College
5200 Kihara Kiyotake, Miyazaki 889-1601 (Japan)
Tel. +81 985 85 2966, Fax +81 985 85 7029
E-Mail tono@post1.miyazaki-med.ac.jp

  

Article Information

Received: Received: November 19, 1999
Accepted after revision: May 22, 2000
Number of Print Pages : 6
Number of Figures : 3, Number of Tables : 2, Number of References : 15

  

Publication Details

ORL (Journal for Oto-Rhino-Laryngology and Its Related Specialties)
Founded 1938 as ‘Practica Oto-Rhino-Laryngologica’ by J. Berberich and E. Schlittler, continued by L. Rüedi 1947–1970, E. Huizinga 1948–1970, C.R. Pfaltz 1968–1984

Vol. 63, No. 1, Year 2001 (Cover Date: January-February 2001)

Journal Editor: W. Arnold, München
ISSN: 0301–1569 (print), 1423–0275 (Online)

For additional information: http://www.karger.com/journals/orl


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 1/26/2001
Issue release date: January–February 2001

Number of Print Pages: 6
Number of Figures: 3
Number of Tables: 2

ISSN: 0301-1569 (Print)
eISSN: 1423-0275 (Online)

For additional information: http://www.karger.com/ORL


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