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Vol. 34, No. 3, 2001
Issue release date: March 2001
Section title: Original Paper
Pediatr Neurosurg 2001;34:124–130
(DOI:10.1159/000056007)

Pathogenesis of Lumbosacral Lipoma: A Test of the ‘Premature Dysjunction’ Theory

Li Y.C. · Shin S.-H. · Cho B.-K. · Lee M.-S. · Lee Y.-J. · Hong S.-K. · Wang K.-C.
aDivision of Pediatric Neurosurgery and Laboratory for Fetal Medicine Research, Clinical Research Institute, Seoul National University Hospital, Seoul, and bDepartment of Neurosurgery, Kangwon National University College of Medicine, Chunchon, Korea

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 5/2/2001

Number of Print Pages: 7
Number of Figures: 9
Number of Tables: 1

ISSN: 1016-2291 (Print)
eISSN: 1423-0305 (Online)

For additional information: http://www.karger.com/PNE

Abstract

Premature separation of the neuroectoderm from the ipsilateral surface ectoderm allowing mesenchymal tissue to invade into the central canal, or ‘premature dysjunction’ theory, was proposed for the pathogenesis of dorsal type lumbosacral lipoma. To test this theory, the unilateral neural fold was incised using Hamburger and Hamilton stage 12 or 13 chick embryos. Among 35 embryos evaluated, 15 showed abnormal findings, and of these one showed findings which suggested lumbosacral lipoma: a back lump, blending of the neuroepithelium and mesenchyme through indistinct basement membrane and vertebral body abnormalities. The other 14 embryos showed abnormalities including blunt tails, open neural tube defects, incomplete closure of the dorsal neuroepithelium with intact skin, skin dimples, disorganized gray matter, scoliosis, ectopic neuroepithelium and an accessory spinal cord. The results revealed that the incision of the unilateral neural fold in the early chick embryo may produce a lesion suggestive of lumbosacral lipoma, a finding which supports the premature dysjunction theory. This method needs further refinement to overcome technical difficulties, high mortality, and a low yield before being adopted as an experimental model for lumbosacral lipoma.


  

Author Contacts

Kyu-Chang Wang, MD, PhD
Division of Pediatric Neurosurgery
Seoul National University Children’s Hospital
28 Yongon-dong, Chongno-gu, Seoul 110-744 (Korea)
Tel. +82 2 760 3489, Fax +82 2 747 5130, E-Mail kcwang@snu.ac.kr

  

Article Information

Received: Received: November 7, 2000
Accepted: February 7, 2001
Number of Print Pages : 7
Number of Figures : 9, Number of Tables : 1, Number of References : 22

  

Publication Details

Pediatric Neurosurgery
Founded 1985 by E.B. Hendrick and D.H. Reigel; Editor-in-Chief 1992–1996: F.J. Epstein
Official Journal of the American Society of Pediatric Neurosurgeons (ASPN)

Vol. 34, No. 3, Year 2001 (Cover Date: March 2001)

Journal Editor: D.G. McLone, Chicago, Ill.
ISSN: 1016–2291 (print), 1423–0305 (Online)

For additional information: http://www.karger.com/journals/pne


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 5/2/2001

Number of Print Pages: 7
Number of Figures: 9
Number of Tables: 1

ISSN: 1016-2291 (Print)
eISSN: 1423-0305 (Online)

For additional information: http://www.karger.com/PNE


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