Pathogenesis of Lumbosacral Lipoma: A Test of the ‘Premature Dysjunction’ TheoryLi Y.C. · Shin S.-H. · Cho B.-K. · Lee M.-S. · Lee Y.-J. · Hong S.-K. · Wang K.-C.
aDivision of Pediatric Neurosurgery and Laboratory for Fetal Medicine Research, Clinical Research Institute, Seoul National University Hospital, Seoul, and bDepartment of Neurosurgery, Kangwon National University College of Medicine, Chunchon, Korea
Premature separation of the neuroectoderm from the ipsilateral surface ectoderm allowing mesenchymal tissue to invade into the central canal, or ‘premature dysjunction’ theory, was proposed for the pathogenesis of dorsal type lumbosacral lipoma. To test this theory, the unilateral neural fold was incised using Hamburger and Hamilton stage 12 or 13 chick embryos. Among 35 embryos evaluated, 15 showed abnormal findings, and of these one showed findings which suggested lumbosacral lipoma: a back lump, blending of the neuroepithelium and mesenchyme through indistinct basement membrane and vertebral body abnormalities. The other 14 embryos showed abnormalities including blunt tails, open neural tube defects, incomplete closure of the dorsal neuroepithelium with intact skin, skin dimples, disorganized gray matter, scoliosis, ectopic neuroepithelium and an accessory spinal cord. The results revealed that the incision of the unilateral neural fold in the early chick embryo may produce a lesion suggestive of lumbosacral lipoma, a finding which supports the premature dysjunction theory. This method needs further refinement to overcome technical difficulties, high mortality, and a low yield before being adopted as an experimental model for lumbosacral lipoma.
Kyu-Chang Wang, MD, PhD
Division of Pediatric Neurosurgery
Seoul National University Children’s Hospital
28 Yongon-dong, Chongno-gu, Seoul 110-744 (Korea)
Tel. +82 2 760 3489, Fax +82 2 747 5130, E-Mail firstname.lastname@example.org
Received: Received: November 7, 2000
Accepted: February 7, 2001
Number of Print Pages : 7
Number of Figures : 9, Number of Tables : 1, Number of References : 22
Founded 1985 by E.B. Hendrick and D.H. Reigel; Editor-in-Chief 1992–1996: F.J. Epstein
Official Journal of the American Society of Pediatric Neurosurgeons (ASPN)
Vol. 34, No. 3, Year 2001 (Cover Date: March 2001)
Journal Editor: D.G. McLone, Chicago, Ill.
ISSN: 1016–2291 (print), 1423–0305 (Online)
For additional information: http://www.karger.com/journals/pne