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Table of Contents
Vol. 65, No. 1, 2002
Issue release date: May 2002
Section title: Original Paper
Pharmacology 2002;65:38–48
(DOI:10.1159/000056184)

Distribution and Muscle-Sparing Effects of Clenbuterol in Hindlimb-Suspended Rats

von Deutsch D.A. · Abukhalaf I.K. · Wineski L.E. · Roper R.R. · Aboul-Enein H.Y. · Paulsen D.F. · Potter D.E.
aSpace Medicine and Life Sciences Research Center, bDepartment of Pharmacology and Toxicology, cClinical Research Center, and dDepartment of Anatomy and Neurobiology, Morehouse School of Medicine, Atlanta,Ga.,USA; eBioanalytical and Drug Development Laboratory, Biological and Medical Research Department, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 3/22/2002

Number of Print Pages: 11
Number of Figures: 5
Number of Tables: 2

ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)

For additional information: http://www.karger.com/PHA

Abstract

Based on their anabolic properties in skeletal muscles, β-adrenergic agonists are of interest as potential countermeasures to microgravity-induced skeletal muscle atrophy. The levels of clenbuterol (Cb), a β2-adrenergic agonist, in both plasma and skeletal muscle were higher in hindlimb-suspended rats than in their nonsuspended Cb-treated controls. Cb treatment was shown to help maintain the body weight in suspended rats, while reducing the amount of mesenteric fat. However, hindlimb suspension attenuated Cb’s lipolytic effects. In skeletal muscle, the magnitude of response to unloading and Cb treatment followed a general regional pattern and was muscle and type specific. The highest magnitude of response to unloading was in predominantly slow-twitch muscles, and the least responsive were the predominately fast-twitch muscles.


  

Author Contacts

Dr. Imad K. Abukhalaf
Department of Pharmacology and Toxicology
Morehouse School of Medicine, 720 Westview Drive, SW
Atlanta, GA 30310-1495 (USA)
Tel. +1 404 756 5228, Fax +1 404 752 1164, E-Mail abukhai@msm.edu

  

Article Information

Received: Received: May 23, 2001
Accepted after revision: July 5, 2001
Number of Print Pages : 11
Number of Figures : 5, Number of Tables : 2, Number of References : 42

  

Publication Details

Pharmacology (International Journal of Experimental and Clinical Pharmacology)
Founded 1959 as ‘Medicina Experimentalis’, continued 1965–1967 as ‘Medicina et Pharmacologia Experimentalis’; Founder: R. Domenjoz (1959–1977); Successors: B.B. Brodie (1968–1977); K. Lederis (1973–1985); K.-F. Sewing (1978–1998); E.S. Vesell (1970–2000)

Vol. 65, No. 1, Year 2002 (Cover Date: May 2002)

Journal Editor: J. Donnerer, Graz; M.L. Billingsley, Hershey, Pa.; T. Watanabe, Sendai; T. Iijima, Akita
ISSN: 0031–7012 (print), 1423–0313 (Online)

For additional information: http://www.karger.com/journals/pha


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 3/22/2002

Number of Print Pages: 11
Number of Figures: 5
Number of Tables: 2

ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)

For additional information: http://www.karger.com/PHA


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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