An Exploratory Study on Obsessive-Compulsive Disorder with and without a Familial Component: Are There Any Phenomenological Differences?Albert U. · Maina G. · Ravizza L. · Bogetto F.
Department of Neuroscience, Anxiety and Mood Disorders Unit, University of Turin, Turin, Italy
Familial studies on obsessive-compulsive disorders (OCD) have suggested that OCD is a heterogeneous condition, with some cases being familial and others being isolated cases in their families. Nevertheless, no studies evaluated whether there are clinical differences between OCD cases with and without a familial component. The current report presents data on the prevalence of OCD in first-degree relatives of OCD probands and compares phenomenological characteristics of familial and non-familial OCD types. The family study and the family history methods were used to estimate the prevalence of OCD in first-degree relatives of 74 OCD probands. A statistical comparison between OCD probands with and without familial loading was performed using Pearson’s χ2 test, Fisher’s exact test, or Student’s t test when appropriate. The rate of OCD was 3.5% in directly interviewed first-degree relatives. Eleven percent of the probands had at least one family member with OCD. There were no differences between the two types of OCD (familial vs. non-familial) except for life events prior to the onset of OCD, which were more common and more severe in non-familial OCD subtypes. In conclusion, our results (1) confirm that there is a familial component in the expression of some forms of OCD and (2) indicate that familial OCD patients are not characterized by peculiar clinical features, but appear to have a lower threshold for precipitating events.
Dr. Giuseppe Maina
Department of Neuroscience, Anxiety and Mood Disorders Unit
University of Turin
Via Cherasco 11, I–10126 Turin (Italy)
Tel. +39 011 633 54 25, Fax +39 011 673 473, E-Mail firstname.lastname@example.org
Number of Print Pages : 9
Number of Figures : 0, Number of Tables : 7, Number of References : 25
Psychopathology (International Journal of Descriptive Psychopathology Phenomenology and Clinical Diagnositcs)
Founded 1897 as ‘Monatsschrift für Psychiatrie und Neurologie’
Vol. 35, No. 1, Year 2002 (Cover Date: January-February 2002)
Journal Editor: E. Gabriel, Vienna; C. Mundt, Heidelberg
ISSN: 0254–4962 (print), 1423–033X (Online)
For additional information: http://www.karger.com/journals/psp