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Vol. 14, Suppl. 1, 2001
Issue release date: August 2001
Section title: Paper
Skin Pharmacol Appl Skin Physiol 2001;14(suppl 1):87–91
(DOI:10.1159/000056395)

Oxidative Targets in the Stratum corneum

A New Basis for Antioxidative Strategies

Thiele J.J.
Department of Dermatology, Friedrich Schiller University, Jena, Germany

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 11/17/2004

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: http://www.karger.com/SPP

Abstract

As the outermost layer of skin, the stratum corneum (SC) is continuously exposed to an oxidative environment, including air pollutants, ultraviolet radiation, chemical oxidants, and aerobic microorganisms. Human SC reveals characteristic antioxidant and protein oxidation gradients with increasing antioxidant depletion and protein oxidation towards the outer layers. SC antioxidants, lipids, and proteins are oxidatively modified upon treatments with ultraviolet A/ultraviolet B, ozone, and benzoyl peroxide. α-Tocopherol represents the predominating SC antioxidant with respect to its concentration and its unique susceptibility to the various oxidative challenges tested. In sites rich in sebaceous glands, α-tocopherol is physiologically delivered to the surface via secretion of sebum. Oxidative damage in the human SC represents an early pathophysiological event preceding barrier disruption and inflammation in environmentally challenged skin. Furthermore, oxidative gradients in SC proteins may have implications for the process of desquamation in human skin.


  

Author Contacts

Jens J. Thiele, MD, Department of Dermatology
Experimental Photodermatology Research Group
Erfurter Strasse 35, D–07740 Jena (Germany)
Tel. +49 3641 937381, Fax +49 3641 937343
E-Mail thiele@derma.uni-jena.de

  

Article Information

Number of Print Pages : 5
Number of Figures : 0, Number of Tables : 0, Number of References : 22

  

Publication Details

Skin Pharmacology and Applied Skin Physiology (Journal of Pharmacological and Biophysical Research)
Incorporating ‘Bioengineering and the Skin’; Founded in 1988 by H. Schaefer
Official Journal of the Skin Pharmacology Society (SPS)

Vol. 14, No. Suppl. 1, Year 2001 (Cover Date: Released August 2001)

Journal Editor: Hans F. Merk, Aachen
ISSN: 1422–2868 (print), 1422–2906 (Online)

For additional information: http://www.karger.com/journals/sph


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 11/17/2004

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: http://www.karger.com/SPP


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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