As the outermost layer of skin, the stratum corneum (SC) is continuously exposed to an oxidative environment, including air pollutants, ultraviolet radiation, chemical oxidants, and aerobic microorganisms. Human SC reveals characteristic antioxidant and protein oxidation gradients with increasing antioxidant depletion and protein oxidation towards the outer layers. SC antioxidants, lipids, and proteins are oxidatively modified upon treatments with ultraviolet A/ultraviolet B, ozone, and benzoyl peroxide. α-Tocopherol represents the predominating SC antioxidant with respect to its concentration and its unique susceptibility to the various oxidative challenges tested. In sites rich in sebaceous glands, α-tocopherol is physiologically delivered to the surface via secretion of sebum. Oxidative damage in the human SC represents an early pathophysiological event preceding barrier disruption and inflammation in environmentally challenged skin. Furthermore, oxidative gradients in SC proteins may have implications for the process of desquamation in human skin.
© 2001 S. Karger AG, Basel
Number of Print Pages : 5
Number of Figures : 0, Number of Tables : 0, Number of References : 22
Skin Pharmacology and Applied Skin Physiology (Journal of Pharmacological and Biophysical Research)
Incorporating ‘Bioengineering and the Skin’; Founded in 1988 by H. Schaefer
Official Journal of the Skin Pharmacology Society (SPS)
Vol. 14, No. Suppl. 1, Year 2001 (Cover Date: Released August 2001)
Journal Editor: Hans F. Merk, Aachen
ISSN: 1422–2868 (print), 1422–2906 (Online)
For additional information: http://www.karger.com/journals/sph
Article / Publication Details
Published online: 11/17/2004
Issue release date: August 2001
Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0
ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)
For additional information: http://www.karger.com/SPP
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