Comparative analysis of the promoter structure and genomic organization of the human and mouse ABCA7 gene encoding a novel ABCA transporterBroccardo C. · Osorio J. · Luciani M.-F. · Schriml L.M. · Prades C. · Shulenin S. · Arnould I. · Naudin L. · Lafargue C. · Rosier M. · Jordan B. · Mattei M.G. · Dean M. · Denèfle P. · Chimini G.
a Centre d’Immunologie INSERM-CNRS de Marseille Luminy, Marseille (France); bEvry Genomics Center, Aventis-Pharma, Evry (France); cCenter for Genomic Diversity, National Cancer Institute, National Institutes of Health, Frederick, MD (USA); and dINSERM Ud00, Marseille (France)
We report here the genomic and transcriptional characterization in mouse and man of a novel transporter of the ABCA subclass, named ABCA7. As it is the case for other ABCA genes, the predicted protein encoded by ABCA7 is a full symmetric transporter, highly conserved across species. The ABCA7 gene maps to human chromosome 19 and to the homologous region at band B4-C1 on mouse chromosome 10. The preferential expression of ABCA7 in the spleen, thymus, and fetal liver is consistent with the finding, in both human and mouse promoter, of sites targeted by lymphomyeloid-specific transcription factors. This suggests that ABCA7 may play a pivotal role in the developmental specification of hematopoietic cell lineages.
Request reprints from Dr. Giovanna Chimini,Centre d’Immunologie de Marseille Luminy, Parc Scientifique de Luminy,case 906, 13288 Marseille Cedex 09 (France);telephone: +33-4-91269404; fax: +33-4-91269430;e-mail: email@example.com.
Supported by institutional grants from INSERM and CNRS and a specific INSERM APEX funding program. C.B. was supported by an ARC fellowship.
Received: Received 30 October 2000;
revision accepted 19 December 2000.
Number of Print Pages : 7
Number of Figures : 4, Number of Tables : 1, Number of References : 28
Cytogenetics and Cell Genetics
Founded 1962 as Cytogenetics by H.P. Klinger
Vol. 92, No. 3-4, Year 2001 (Cover Date: 2001)
Journal Editor: H.P. Klinger, Bronx, N.Y.; M. Schmid, Würzburg
ISSN: 0301–0171 (print), 1422–9816 (Online)
For additional information: http://www.karger.com/journals/ccg