The human hedgehog-interacting protein gene: Structure and chromosome mapping to 4q31.21→q31.3Bak M. · Hansen C. · Friis Henriksen K. · Tommerup N.
Department of Medical Genetics, Institute of Medical Biochemistry and Genetics, The Panum Institute, University of Copenhagen (Denmark)
Hedgehog-interacting protein (Hhip) is a novel regulatory component in the vertebrate hedgehog-signalling pathway. The murine Hhip encodes a type I TM protein that attenuates hedgehog signalling by binding all three mammalian hedgehog proteins. Here we describe the cloning and characterisation of the homologous human hedgehog-interacting protein gene (HHIP). HHIP comprises 13 exons and spans >91kb encoding a protein of 700 aa which shares 94% sequence iden- tity with mouse Hhip. HHIP maps to chromosome 4q31.21→ q31.3. Additionally, we have mapped murine Hhip to chromosome 8.
© 2001 S. Karger AG, Basel
Request reprints from Niels Tommerup, Department of Medical Genetics G,Institute of Medical Biochemistry and Genetics, Panum Institute,University of Copenhagen. Blegdamsvej 3, Bldg 24.4.DK–2200 Copenhagen N. (Denmark); telephone:(+45) 35327826;fax:(+45) 35327845; email: email@example.com
Supported by the Danish Biotechnological Research and Development Program 1996–1998. The Danish Environmental Research Program, The Danish Research Councils (9902161, 9700832), The Danish Cancer Society (scholarship to M.B.), The Danish Heart Foundation, Novo Nordisk Foundation, Aage Bangs Foundation, Deutsche Bundesministerium für Forschung und Technologie (01KW99087) and the EU-Commission (BMH4-CT97-2268, QLG1-CT-2000-01019).
Received: Received 8 November 2000;
manuscript accepted 19 December 2000.
Number of Print Pages : 4
Number of Figures : 1, Number of Tables : 1, Number of References : 9
Cytogenetics and Cell Genetics
Founded 1962 as Cytogenetics by H.P. Klinger
Vol. 92, No. 3-4, Year 2001 (Cover Date: 2001)
Journal Editor: H.P. Klinger, Bronx, N.Y.; M. Schmid, Würzburg
ISSN: 0301–0171 (print), 1422–9816 (Online)
For additional information: http://www.karger.com/journals/ccg